Annu's Hospitals for Skin and Diabetes, Nellore, Andhra Pradesh, India.
Department of Electronics and Communications Engineering, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India.
Angiology. 2020 Jul;71(6):520-535. doi: 10.1177/0003319720910660. Epub 2020 Mar 17.
We evaluated the association between automatically measured carotid total plaque area (TPA) and the estimated glomerular filtration rate (eGFR), a biomarker of chronic kidney disease (CKD). Automated average carotid intima-media thickness (cIMTave) and TPA measurements in carotid ultrasound (CUS) were performed using AtheroEdge (AtheroPoint). Pearson correlation coefficient (CC) was then computed between the TPA and eGFR for (1) males versus females, (2) diabetic versus nondiabetic patients, and (3) between the left and right carotid artery. Overall, 339 South Asian Indian patients with either type 2 diabetes mellitus (T2DM) or CKD, or hypertension (stage 1 or stage 2) were retrospectively analyzed by acquiring cIMTave and TPA measurements of their left and right common carotid arteries (CCA; total CUS: 678, mean age: 54.2 ± 9.8 years; 75.2% males; 93.5% with T2DM). The CC between TPA and eGFR for different scenarios were (1) for males and females -0.25 ( < .001) and -0.35 ( < .001), respectively; (2) for T2DM and non-T2DM -0.26 ( < .001) and -0.49 ( = .02), respectively, and (3) for left and right CCA -0.25 ( < .001) and -0.23 ( < .001), respectively. Automated TPA is an equally reliable biomarker compared with cIMTave for patients with CKD (with or without T2DM) with subclinical atherosclerosis.
我们评估了颈动脉总斑块面积（TPA）与估算肾小球滤过率（eGFR）之间的关联，eGFR 是慢性肾脏病（CKD）的生物标志物。颈动脉超声（CUS）中的自动平均颈动脉内膜中层厚度（cIMTave）和 TPA 测量使用 AtheroEdge（AtheroPoint）进行。然后，计算了 TPA 与 eGFR 之间的 Pearson 相关系数（CC），用于（1）男性与女性，（2）糖尿病患者与非糖尿病患者，以及（3）左右颈动脉之间。总体而言，通过获取左右颈总动脉的 cIMTave 和 TPA 测量值，对 339 名南亚印度患者（患有 2 型糖尿病（T2DM）或 CKD 或高血压（1 期或 2 期））进行了回顾性分析（总 CUS：678，平均年龄：54.2±9.8 岁；75.2%为男性；93.5%患有 T2DM）。不同情况下 TPA 与 eGFR 之间的 CC 分别为：（1）男性和女性分别为-0.25（<0.001）和-0.35（<0.001）；（2）T2DM 和非 T2DM 分别为-0.26（<0.001）和-0.49（=0.02）；（3）左右 CCA 分别为-0.25（<0.001）和-0.23（<0.001）。对于伴有或不伴有 T2DM 的亚临床动脉粥样硬化的 CKD 患者，自动 TPA 是与 cIMTave 一样可靠的生物标志物。
