Aykaç Ahmet, Gergeroglu Hazal, Beşli Büşra, Akkaş Emine Özge, Yavaş Ahmet, Güler Saadet, Güneş Fethullah, Erol Mustafa
Department of Engineering Sciences, Izmir Katip Çelebi University, 35620, Izmir, Turkey.
Department of Nanoscience and Nanotechnology, Izmir Katip Çelebi University, 35620, Izmir, Turkey.
Nanoscale Res Lett. 2021 Apr 20;16(1):65. doi: 10.1186/s11671-021-03519-w.
Nanobiosensors are convenient, practical, and sensitive analyzers that detect chemical and biological agents and convert the results into meaningful data between a biologically active molecule and a recognition element immobilized on the surface of the signal transducer by a physicochemical detector. Due to their fast, accurate and reliable operating characteristics, nanobiosensors are widely used in clinical and nonclinical applications, bedside testing, medical textile industry, environmental monitoring, food safety, etc. They play an important role in such critical applications. Therefore, the design of the biosensing interface is essential in determining the performance of the nanobiosensor. The unique chemical and physical properties of nanomaterials have paved the way for new and improved sensing devices in biosensors. The growing demand for devices with improved sensing and selectivity capability, short response time, lower limit of detection, and low cost causes novel investigations on nanobiomaterials to be used as biosensor scaffolds. Among all other nanomaterials, studies on developing nanobiosensors based on metal oxide nanostructures, graphene and its derivatives, carbon nanotubes, and the widespread use of these nanomaterials as a hybrid structure have recently attracted attention. Nanohybrid structures created by combining these nanostructures will directly meet the future biosensors' needs with their high electrocatalytic activities. This review addressed the recent developments on these nanomaterials and their derivatives, and their use as biosensor scaffolds. We reviewed these popular nanomaterials by evaluating them with comparative studies, tables, and charts.
纳米生物传感器是便捷、实用且灵敏的分析仪，可检测化学和生物制剂，并通过物理化学检测器将结果转化为生物活性分子与固定在信号换能器表面的识别元件之间有意义的数据。由于其快速、准确和可靠的操作特性，纳米生物传感器广泛应用于临床和非临床应用、床边检测、医用纺织工业、环境监测、食品安全等领域。它们在这些关键应用中发挥着重要作用。因此，生物传感界面的设计对于确定纳米生物传感器的性能至关重要。纳米材料独特的化学和物理性质为生物传感器中新型且改进的传感装置铺平了道路。对具有更高传感和选择性能力、更短响应时间、更低检测限以及低成本的装置的需求不断增长，促使人们对用作生物传感器支架的纳米生物材料展开新的研究。在所有其他纳米材料中，基于金属氧化物纳米结构、石墨烯及其衍生物、碳纳米管开发纳米生物传感器的研究以及这些纳米材料作为混合结构的广泛应用最近受到了关注。通过组合这些纳米结构形成的纳米混合结构将凭借其高电催化活性直接满足未来生物传感器的需求。本综述阐述了这些纳米材料及其衍生物的最新进展，以及它们作为生物传感器支架的用途。我们通过比较研究、表格和图表对这些热门纳米材料进行了评估。
