Florida State University College of Medicine, United States.
Florida State University College of Medicine, United States.
Arch Gerontol Geriatr. 2020 May-Jun;88:104033. doi: 10.1016/j.archger.2020.104033. Epub 2020 Mar 5.
A meaningful and purpose-driven life is associated with better health outcomes. We test whether meaning in life is associated with risk of cognitive impairment using data from a large, multi-national study.
Participants (N = 22,514) were from the Survey of Health, Ageing and Retirement in Europe (SHARE). Participants from 14 countries reported on their meaning in life. Cognitive impairment was derived from performance on cognitive tasks administered at baseline and at up to three follow-up waves (waves 2-6 assessed between 2010-2015).
Lack of meaning in life was associated with a more than 20 % increased risk of incident cognitive impairment over the up to 9-year follow-up (Hazard Ratio = 1.24; 95 % Confidence Interval = 1.17-1.31). Further, compared to participants who reported often feeling meaning in life, participants who reported never feeling meaning in life were at an approximately 75 % increased risk of impairment (Hazard Ratio = 1.75, 95 % Confidence Interval = 1.19-2.57). The association between meaning in life and risk of cognitive impairment was apparent across four regions of Europe (Northern, Southern, Eastern, Western) and in Israel and was not moderated by sociodemographic characteristics.
Reporting lower meaning in one's life is associated with risk of incident cognitive impairment. Meaning may be a potential target of intervention for healthier cognitive aging.
有意义和有目的的生活与更好的健康结果相关。我们使用来自大型跨国研究的数据来检验生活意义是否与认知障碍风险相关。
参与者（N=22514）来自欧洲健康、衰老和退休调查（SHARE）。来自 14 个国家的参与者报告了他们的生活意义。认知障碍是根据在基线和最多三次随访期间（2010-2015 年评估的第 2-6 波）进行的认知任务表现得出的。
缺乏生活意义与认知障碍的发生率增加 20%以上相关，在长达 9 年的随访中（风险比=1.24；95%置信区间=1.17-1.31）。此外，与经常感到生活有意义的参与者相比，从不感到生活有意义的参与者发生认知障碍的风险增加了约 75%（风险比=1.75，95%置信区间=1.19-2.57）。生活意义与认知障碍风险之间的关联在欧洲的四个地区（北部、南部、东部和西部）以及以色列都很明显，并且不受社会人口特征的调节。
报告生活意义较低与认知障碍的发生风险相关。意义可能是更健康的认知老化的潜在干预目标。
