Department of Microbiology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, 18071 Granada, Spain.
Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, 18016 Armilla, Granada, Spain.
Nutrients. 2020 Mar 13;12(3):757. doi: 10.3390/nu12030757.
Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus . This work presents the compiled and analysed results from the most up-to-date information from clinical trials regarding microbiota, fertility, probiotics and oral route administration, reviewing open access scientific documents. These studies analyse the clinical impact of probiotics administered on several endocrine disorders' manifestations in women: mastitis; vaginal dysbiosis; pregnancy complication disorders; and polycystic ovary syndrome. In all cases, the clinical modulation achieved by probiotics was evaluated positively through the improvement of specific disease outcomes with the exception of the pregnancy disorders studies, where the sample sizes results were statistically insufficient. High amounts of studies were discarded because no data were provided on specific probiotic strains, doses, impact on the individual autochthon microbiota, or data regarding specific hormonal values modifications and endocrine regulation effects. However, most of the selected studies with probiotics contained no protocolised administration. Therefore, we consider that intervention studies with probiotics might allocate the focus, not only in obtaining a final outcome, but in how to personalise the administration according to the disorder to be palliated.
人体微生物群似乎在内分泌和生殖系统中发挥着关键作用。幸运的是，生殖微生态失调开始通过使用属中的典型物种来治疗益生菌。这项工作展示了从临床试验中关于微生物群、生育能力、益生菌和口服途径管理的最新信息中编译和分析的结果，审查了开放获取的科学文献。这些研究分析了益生菌给药对女性几种内分泌疾病表现的临床影响：乳腺炎；阴道微生态失调；妊娠并发症疾病；和多囊卵巢综合征。在所有情况下，通过改善特定疾病结局来评估益生菌的临床调节作用，除了妊娠疾病研究外，这些研究的样本量结果在统计学上不足。大量的研究被剔除，因为没有提供特定益生菌菌株、剂量、对个体自生菌群的影响，或特定激素值变化和内分泌调节作用的数据。然而，大多数含有益生菌的选定研究都没有规定管理方案。因此，我们认为益生菌的干预研究不仅要关注最终结果，还要关注如何根据需要缓解的疾病来个性化管理。
