• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

联合治疗策略协同增强胶质母细胞瘤多形性治疗纳米技术。

Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment nanotechnology.

机构信息

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.

University of Chinese Academy of Sciences, Beijing 100049, PR China.

出版信息

Theranostics. 2020 Feb 10;10(7):3223-3239. doi: 10.7150/thno.40298. eCollection 2020.

DOI:10.7150/thno.40298
PMID:32194864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7053190/
Abstract

Glioblastoma multiforme (GBM) is a highly aggressive and devastating brain tumor characterized by poor prognosis and high rates of recurrence. Numerous therapeutic strategies and delivery systems are developed to prolong the survival time. They exhibit enhanced therapeutic effects in animal models, whereas few of them is applied in clinical trials. Taking into account the drug-resistance and high recurrence of GBM, combined-therapeutic strategies are exploited to maximize therapeutic efficacy. The combined therapies demonstrate superior results than those of single therapies against GBM. The co-therapeutic agents, the timing of therapeutic strategies and the delivery systems greatly affect the overall outcomes. Herein, the current advances in combined therapies for glioblastoma systemic administration are exhibited in this review. And we will discuss the pros and cons of these combined-therapeutic strategies nanotechnology, and provide the guidance for developing rational delivery systems to optimize treatments against GBM and other malignancies in central nervous system.

摘要

多形性胶质母细胞瘤（GBM）是一种高度侵袭性和破坏性的脑肿瘤，其预后不良，复发率高。为了延长生存时间，开发了许多治疗策略和给药系统。它们在动物模型中表现出增强的治疗效果，但其中很少应用于临床试验。考虑到 GBM 的耐药性和高复发率，联合治疗策略被用来最大限度地提高治疗效果。与单一疗法相比，联合疗法对 GBM 具有更好的效果。联合治疗药物、治疗策略的时机和给药系统对整体结果有很大影响。本文综述了 GBM 系统给药的联合治疗的最新进展。我们将讨论这些联合治疗策略的优缺点，纳米技术，并为开发合理的给药系统以优化针对 GBM 和中枢神经系统其他恶性肿瘤的治疗提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6efccf713197/thnov10p3223g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/dd6be687cefa/thnov10p3223g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/da63bef6c037/thnov10p3223g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/8df633071b4e/thnov10p3223g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/90f2da3d63b3/thnov10p3223g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/725d7cc356e1/thnov10p3223g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6b678831ca1a/thnov10p3223g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/313dd187a8cf/thnov10p3223g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/858a1c1da5b3/thnov10p3223g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6f0b2ee6695b/thnov10p3223g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/26dd03a349ba/thnov10p3223g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/e4ee63cbad2b/thnov10p3223g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/603a4060f124/thnov10p3223g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/3f6c391ebec3/thnov10p3223g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6efccf713197/thnov10p3223g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/dd6be687cefa/thnov10p3223g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/da63bef6c037/thnov10p3223g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/8df633071b4e/thnov10p3223g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/90f2da3d63b3/thnov10p3223g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/725d7cc356e1/thnov10p3223g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6b678831ca1a/thnov10p3223g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/313dd187a8cf/thnov10p3223g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/858a1c1da5b3/thnov10p3223g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6f0b2ee6695b/thnov10p3223g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/26dd03a349ba/thnov10p3223g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/e4ee63cbad2b/thnov10p3223g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/603a4060f124/thnov10p3223g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/3f6c391ebec3/thnov10p3223g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2203/7053190/6efccf713197/thnov10p3223g014.jpg

相似文献

1
Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment nanotechnology.联合治疗策略协同增强胶质母细胞瘤多形性治疗纳米技术。
Theranostics. 2020 Feb 10;10(7):3223-3239. doi: 10.7150/thno.40298. eCollection 2020.
2
Glioblastoma multiforme: a glance at advanced therapies based on nanotechnology.多形性胶质母细胞瘤：纳米技术为基础的先进疗法概览。
J Chemother. 2020 May;32(3):107-117. doi: 10.1080/1120009X.2020.1713508. Epub 2020 Jan 25.
3
Drug delivery approaches for the treatment of glioblastoma multiforme.用于治疗多形性胶质母细胞瘤的药物输送方法。
Artif Cells Nanomed Biotechnol. 2016 Sep;44(6):1365-73. doi: 10.3109/21691401.2015.1052467. Epub 2015 Jun 5.
4
Nanotechnology to augment immunotherapy for the treatment of glioblastoma multiforme.用于增强免疫疗法治疗多形性胶质母细胞瘤的纳米技术。
J Neurooncol. 2015 Jul;123(3):473-81. doi: 10.1007/s11060-015-1814-1. Epub 2015 Jun 13.
5
Use of nanoparticles for drug delivery in glioblastoma multiforme.纳米颗粒在多形性胶质母细胞瘤药物递送中的应用。
Expert Rev Neurother. 2007 Apr;7(4):363-72. doi: 10.1586/14737175.7.4.363.
6
Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems.利用基于纳米颗粒的递药系统增强胶质母细胞瘤（GBM）的治疗效果。
AAPS PharmSciTech. 2021 Feb 11;22(2):71. doi: 10.1208/s12249-021-01928-9.
7
Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma.靶向递送达功能化上转换纳米颗粒用于脑胶质母细胞瘤的外部触发光热/光动力治疗。
Theranostics. 2018 Feb 4;8(5):1435-1448. doi: 10.7150/thno.22482. eCollection 2018.
8
Nanotechnology meets glioblastoma multiforme: Emerging therapeutic strategies.纳米技术与多形性胶质母细胞瘤：新兴治疗策略
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Jan;15(1):e1838. doi: 10.1002/wnan.1838. Epub 2022 Aug 12.
9
Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma.用于热疗的纳米颗粒：合成策略及其在胶质母细胞瘤中的应用
Int J Nanomedicine. 2014 Jun 10;9:2863-77. doi: 10.2147/IJN.S57501. eCollection 2014.
10
Current Perspectives on Therapies, Including Drug Delivery Systems, for Managing Glioblastoma Multiforme.治疗胶质母细胞瘤的新视角，包括药物传递系统。
ACS Chem Neurosci. 2020 Oct 7;11(19):2962-2977. doi: 10.1021/acschemneuro.0c00555. Epub 2020 Sep 18.

引用本文的文献

1
Lipid-based nanocarriers in combination chemotherapy: a promising strategy for advanced skin cancer management.基于脂质的纳米载体在联合化疗中：一种用于晚期皮肤癌治疗的有前景的策略。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 15. doi: 10.1007/s00210-025-04431-1.
2
Glioblastoma at the crossroads: current understanding and future therapeutic horizons.处于十字路口的胶质母细胞瘤：当前的认识与未来的治疗前景
Signal Transduct Target Ther. 2025 Jul 9;10(1):213. doi: 10.1038/s41392-025-02299-4.
3
Prevalence and Independent Risk Factors of Anxiety and Depression Symptoms in Glioma Patients: A Cross-Sectional Analysis.

本文引用的文献

1
Thermal monitoring during photothermia: hybrid probes for simultaneous plasmonic heating and near-infrared optical nanothermometry.光热治疗中的热监测：用于等离子体加热和近红外光热测量的混合探针。
Theranostics. 2019 Sep 25;9(24):7298-7312. doi: 10.7150/thno.38091. eCollection 2019.
2
Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment.载有替莫唑胺的多功能脂质超顺磁纳米载体：协同化疗和热疗对脑胶质瘤球的双重靶向和破坏。
Nanoscale. 2019 Nov 28;11(44):21227-21248. doi: 10.1039/c9nr07976a. Epub 2019 Oct 30.
3
胶质瘤患者焦虑和抑郁症状的患病率及独立危险因素：一项横断面分析。
Psychiatry Clin Psychopharmacol. 2025 Apr 18;35(2):155-164. doi: 10.5152/pcp.2025.241021. eCollection 2025 Jun.
4
From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy.从冷到热：热疗调节肿瘤免疫以增强免疫治疗的机制
Front Immunol. 2025 Feb 28;16:1487296. doi: 10.3389/fimmu.2025.1487296. eCollection 2025.
5
Inorganic Nanoparticles-based Drug Delivery Systems for Neurodegenerative Diseases Therapy.用于神经退行性疾病治疗的无机纳米颗粒药物递送系统
Curr Pharm Des. 2025;31(25):1998-2024. doi: 10.2174/0113816128352935250116064725.
6
Nanoplatforms for Magnetic-Photo-Heating of Thermo-Resistant Tumor Cells: Singular Synergic Therapeutic Effects at Mild Temperature.用于耐热肿瘤细胞磁光热疗的纳米平台：温和温度下的独特协同治疗效果
Small. 2024 Dec;20(51):e2310522. doi: 10.1002/smll.202310522. Epub 2024 Oct 28.
7
Clinical and translational advances in primary brain tumor therapy with a focus on glioblastoma-A comprehensive review of the literature.原发性脑肿瘤治疗的临床与转化进展，重点关注胶质母细胞瘤——文献综述
World Neurosurg X. 2024 Sep 21;24:100399. doi: 10.1016/j.wnsx.2024.100399. eCollection 2024 Oct.
8
Liposomal Nanomaterials: A Rising Star in Glioma Treatment.脂质体纳米材料：脑胶质瘤治疗的后起之秀。
Int J Nanomedicine. 2024 Jul 5;19:6757-6776. doi: 10.2147/IJN.S470478. eCollection 2024.
9
Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma.肽搭乘用于神经胶质瘤中纳米系统的发展。
ACS Nano. 2024 Jul 2;18(26):16359-16394. doi: 10.1021/acsnano.4c01790. Epub 2024 Jun 11.
10
New insights into targeted therapy of glioblastoma using smart nanoparticles.利用智能纳米颗粒对胶质母细胞瘤进行靶向治疗的新见解。
Cancer Cell Int. 2024 May 7;24(1):160. doi: 10.1186/s12935-024-03331-3.
Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy.
血脑屏障通透性纳米免疫缀合物诱导局部免疫反应治疗神经胶质瘤。
Nat Commun. 2019 Aug 28;10(1):3850. doi: 10.1038/s41467-019-11719-3.
4
Mechanisms of immunotherapy resistance: lessons from glioblastoma.免疫疗法耐药机制：胶质母细胞瘤的启示。
Nat Immunol. 2019 Sep;20(9):1100-1109. doi: 10.1038/s41590-019-0433-y. Epub 2019 Jul 29.
5
ROS-Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy.ROS 响应性三重复合相互作用稳定的聚合物 siRNA 纳米医学用于稳健的胶质母细胞瘤联合 RNAi 治疗。
Adv Mater. 2019 Sep;31(37):e1903277. doi: 10.1002/adma.201903277. Epub 2019 Jul 26.
6
Liposomal formulations of photosensitizers.脂质体剂型的光敏剂。
Biomaterials. 2019 Oct;218:119341. doi: 10.1016/j.biomaterials.2019.119341. Epub 2019 Jul 10.
7
Magnetic targeting combined with active targeting of dual-ligand iron oxide nanoprobes to promote the penetration depth in tumors for effective magnetic resonance imaging and hyperthermia.磁靶向联合双配体氧化铁纳米探针的主动靶向以提高肿瘤穿透深度用于有效的磁共振成像和热疗。
Acta Biomater. 2019 Sep 15;96:491-504. doi: 10.1016/j.actbio.2019.07.017. Epub 2019 Jul 11.
8
A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma.一种携带 p53 基因的肿瘤靶向纳米医学药物能够穿透血脑屏障，并增强胶质母细胞瘤小鼠模型的抗 PD-1 免疫治疗效果。
Int J Cancer. 2019 Nov 1;145(9):2535-2546. doi: 10.1002/ijc.32531. Epub 2019 Jul 8.
9
Emerging blood-brain-barrier-crossing nanotechnology for brain cancer theranostics.用于脑癌治疗学的新兴血脑屏障穿透纳米技术。
Chem Soc Rev. 2019 Jun 4;48(11):2967-3014. doi: 10.1039/c8cs00805a.
10
Scaffolds biomimicking macrophages for a glioblastoma NIR-Ib imaging guided photothermal therapeutic strategy by crossing Blood-Brain Barrier.通过血脑屏障交叉，支架仿生巨噬细胞用于神经胶质瘤近红外 Ib 成像引导光热治疗策略。
Biomaterials. 2019 Aug;211:48-56. doi: 10.1016/j.biomaterials.2019.04.026. Epub 2019 May 6.