Yaghoubi Sajad, Najminejad Hamid, Dabaghian Mehran, Karimi Mohammad Hossein, Abdollahpour-Alitappeh Meghdad, Rad Fariba, Mahi-Birjand Motahareh, Mohammadi Shiva, Mohseni Fatemeh, Sobhani Lari Mohammad, Teymouri Gholam Hossein, Rigi Yousofabadi Esmat, Salmani Abbas, Bagheri Nader
Department of Clinical Microbiology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
IUBMB Life. 2020 Jul;72(7):1286-1305. doi: 10.1002/iub.2275. Epub 2020 Mar 20.
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.
外泌体作为天然存在的囊泡，在缺血性疾病和不同肿瘤的发生发展及转归中发挥着极其重要的作用。缺血性疾病中的缺氧和肿瘤微环境对外泌体的分泌、组成及功能均有显著影响。缺氧细胞分泌的外泌体通过多种信号通路影响缺血性疾病和肿瘤的发育、生长、血管生成及进展。在这篇综述文章中，我们探讨了缺氧如何影响外泌体的数量和质量，并综述了缺氧细胞来源的外泌体调节癌细胞和非癌细胞中缺血细胞行为的机制。
