College of Pharmacy, Seoul National University, Seoul 08826, Korea.
College of Pharmacy, Dongduk Women's University, Seoul 08826, Korea.
Int J Environ Res Public Health. 2020 Mar 18;17(6):1978. doi: 10.3390/ijerph17061978.
Atopic disease is associated with chronic inflammation, and anemia has been reported in patients with inflammatory disorders such as rheumatoid arthritis, chronic obstructive pulmonary disease, and irritable bowel disease. The objective of this study was to determine whether atopic disease is associated with an increased risk of anemia. A cross-sectional study with propensity score weighting was conducted using a health insurance review agency claims dataset comprised of randomized patients who used the Korean national health system at least once in 2016. The association between atopic disease (asthma, atopic dermatitis, allergic rhinitis) and anemia (iron deficiency anemia (IDA) and/or anemia of inflammation (AI)) was examined. A total of 1,468,033 patients were included in this study. The IDA/AI prevalence was 3.1% (45,681 patients). After propensity score weighting, there were 46,958 and 45,681 patients in the non-anemic and anemic groups, respectively. The prevalence of IDA/AI in patients with atopic dermatitis, allergic rhinitis, or asthma had an odds ratio (OR) of 1.40 (95% confidence interval (CI), 1.33-1.48; < 0.001), 1.17 (95% CI, 1.14-1.21; < 0.001), and 1.32 (95% CI, 1.28-1.36; < 0.001), respectively. In addition, the prevalence of IDA increased with higher numbers of atopic diseases. In conclusion, the prevalence of IDA/AI was higher in patients with atopic disease, even after adjusting for demographic characteristics and other risk factors. Further study is needed to distinguish between IDA and AI and to enhance understanding of the etiology of anemia in patients with inflammatory conditions.
特应性疾病与慢性炎症有关，已有研究报道，类风湿关节炎、慢性阻塞性肺疾病和肠易激综合征等炎症性疾病患者会出现贫血。本研究旨在确定特应性疾病是否与贫血风险增加相关。采用倾向评分加权的回顾性队列研究，使用韩国健康保险审查和评估服务机构于 2016 年收集的健康保险理赔数据，纳入至少使用过一次韩国国家健康系统的随机患者。分析特应性疾病（哮喘、特应性皮炎、过敏性鼻炎）与贫血（缺铁性贫血（IDA）和/或炎症性贫血（AI））之间的相关性。共纳入 1468033 例患者。IDA/AI 的患病率为 3.1%（45681 例）。经倾向评分加权后，非贫血组和贫血组分别有 46958 例和 45681 例患者。特应性皮炎、过敏性鼻炎或哮喘患者发生 IDA/AI 的比值比（OR）分别为 1.40（95%置信区间（CI）：1.33-1.48；<0.001）、1.17（95%CI：1.14-1.21；<0.001）和 1.32（95%CI：1.28-1.36；<0.001）。此外，随着特应性疾病数量的增加，IDA 的患病率也随之增加。综上，特应性疾病患者的 IDA/AI 患病率较高，即使在调整了人口统计学特征和其他危险因素后依然如此。需要进一步研究以区分 IDA 和 AI，并深入了解炎症性疾病患者贫血的病因。
