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There are some controversies about the involvement of microRNA (miR)-19a-3p in hepatocellular carcinoma (HCC) biology, even though many studies have shown that it plays an important role in cancer. In this study, we found that miR-19a-3p is usually overexpressed in HCC tissues compared with corresponding peritumorous tissues, and its expression was associated with tumor size and poor overall survival. MiR-19a-3p promoted cell proliferation significantly, and more cells were found in the S phase. In vivo, miR-19a-3p promoted liver tumor growth, and more HCC cells were found in the active cell cycle. Sequencing and bioinformatics analysis predicted that is a likely target gene of miR-19a-3p, and we next confirmed it by luciferase and rescue assays. Altogether, our data showed an important role of PIK3IP1 downregulation by miR-19a-3p in HCC progression, and the miR-19a-3p-PIK3IP1-AKT pathway may be a potential therapeutic target.

尽管许多研究表明微小RNA（miR）-19a-3p在癌症中发挥重要作用，但关于其在肝细胞癌（HCC）生物学中的作用仍存在一些争议。在本研究中，我们发现与相应的癌旁组织相比，miR-19a-3p在HCC组织中通常过表达，并且其表达与肿瘤大小和较差的总生存期相关。miR-19a-3p显著促进细胞增殖，并且在S期发现更多细胞。在体内，miR-19a-3p促进肝肿瘤生长，并且在活跃细胞周期中发现更多HCC细胞。测序和生物信息学分析预测是miR-19a-3p的一个潜在靶基因，接下来我们通过荧光素酶和拯救实验证实了这一点。总之，我们的数据表明miR-19a-3p下调PIK3IP1在HCC进展中起重要作用，并且miR-19a-3p-PIK3IP1-AKT通路可能是一个潜在的治疗靶点。

注

原文中“Sequencing and bioinformatics analysis predicted that is a likely target gene of miR-19a-3p”这里“预测的潜在靶基因”表述不完整，原文少了具体基因名。已按完整翻译流程翻译，但该部分内容缺失会影响整体逻辑完整性。