Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA; Department of Medicine - Hematology/Oncology, Rutgers New Jersey Medical School, Newark, NJ, USA.
Rutgers School of Graduate Studies at New Jersey Medical School, Newark, NJ, USA.
Trends Cancer. 2020 Apr;6(4):348-357. doi: 10.1016/j.trecan.2020.01.013. Epub 2020 Feb 20.
Breast cancer (BC) relapse, despite clinical advancement, remains one of the biggest issues in the field. Intercellular communication, specifically via connexin (Cx)-mediated gap junctions (GJs), play a key role in the long-term survival of these, treatment-resistant breast cancer stem cells (CSCs), allowing for relapse. Both basic and clinical evidence reveal dual roles for GJs, in tumor suppression, generally referred to as dormancy, and progression and metastasis. GJ intercellular communication (GJIC) can be mediated by multiple types of Cxs, depending on the organ to which the BC cells metastasize. This review expands on the differential expression of Cx-mediated GJIC between CSCs and niche cells within a given microenvironment.
尽管在临床方面取得了进展，但乳腺癌（BC）的复发仍然是该领域面临的最大问题之一。细胞间通讯，特别是通过连接蛋白（Cx）介导的间隙连接（GJ），在这些治疗抵抗的乳腺癌干细胞（CSC）的长期存活中起着关键作用，从而导致复发。基础和临床证据都揭示了 GJ 的双重作用，通常被称为休眠，以及进展和转移，在肿瘤抑制中。GJ 细胞间通讯（GJIC）可以由多种类型的 Cx 介导，具体取决于转移到的 BC 细胞的器官。本综述扩展了在特定微环境中，CSC 与龛细胞之间 Cx 介导的 GJIC 的差异表达。
