Faculty of Agriculture and Food, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming, Yunnan 650500, China.
Faculty of Agriculture and Food, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming, Yunnan 650500, China.
Food Chem. 2020 Aug 1;320:126618. doi: 10.1016/j.foodchem.2020.126618. Epub 2020 Mar 15.
Acute and subacute studies of rambutan peel phenolic (RPP) extract were conducted by oral administration on Kunming mice and Sprague-Dawley (SD) rats, respectively. Acute toxicity study (14 days) results revealed that the LD value of RPP extract was more than 5000 mg/kg bw in vivo. For the subacute study, four different doses were administered to SD rats by daily gavage for 28 days. Subacute toxicity study results indicated that RPP extract did not show any obvious adverse effect at doses of 312 and 625 mg/kg bw. The bw gain was significantly inhibited at 2500 mg/kg bw of RPP extract. RPP extract at doses of 1250 and 2500 mg/kg bw showed toxicities to liver, kidney, and spleen in SD rats according to the results of hematological and biochemical analyses. Furthermore, RPP extract at 2500 mg/kg bw showed toxicity on different tissues according to the results of histopathological analyses.
对红毛丹果皮酚（RPP）提取物进行了急性和亚急性研究，分别通过口服给予昆明小鼠和 Sprague-Dawley（SD）大鼠。急性毒性研究（14 天）结果表明，RPP 提取物在体内的 LD 值大于 5000mg/kg bw。对于亚急性研究，以每天灌胃的方式将四种不同剂量的 RPP 提取物给予 SD 大鼠，持续 28 天。亚急性毒性研究结果表明，RPP 提取物在 312 和 625mg/kg bw 剂量下没有表现出任何明显的不良影响。在 2500mg/kg bw 的 RPP 提取物剂量下，体重增加受到显著抑制。根据血液学和生化学分析的结果，RPP 提取物在 1250 和 2500mg/kg bw 剂量下对 SD 大鼠的肝脏、肾脏和脾脏表现出毒性。此外，根据组织病理学分析的结果，RPP 提取物在 2500mg/kg bw 剂量下对不同组织表现出毒性。
