School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Sensors (Basel). 2020 Mar 27;20(7):1854. doi: 10.3390/s20071854.
Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services.
虽然基于 ELISA 的既定传感平台具有许多优势，但细胞因子和癌症生物标志物检测对即时诊断的重要性推动了人们对更具特异性、灵敏度、简便、易用和经济的传感器的寻找。基于纸张的生物传感器有望在未来的现场应用中得到应用，并能提供快速分析和数据，而无需在实验室中进行。电化学检测在从定性评估到定量测定的结果解释中起着至关重要的作用。在这篇综述中，强调并深入讨论了影响电化学基于纸张的生物传感器设计的各种因素。综述了不同的检测方法，以及利用这些方法在细胞因子和癌症生物标志物检测中的最新进展。最后，便携式电化学基于纸张的生物传感器的制造在考虑到资源有限和医疗服务可及性有限的发展中国家具有积极的社会影响。
