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临床前模型：增强协同作用以改善转化效果。

Preclinical Models: Boosting Synergies for Improved Translation.

作者信息

Attanasio Chiara, Sangiovanni Mara

机构信息

Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Napoli, Italy.

Center for Advanced Biomaterials for Health Care-Istituto Italiano di Tecnologia, 80125 Napoli, Italy.

出版信息

J Clin Med. 2020 Apr 3;9(4):1011. doi: 10.3390/jcm9041011.

DOI:10.3390/jcm9041011
PMID:32260102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7230432/
Abstract

The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...].

摘要

临床前模型领域是一个非常广阔的舞台，在这个舞台上，要在看似非常遥远的研究领域中开展工作的各个群体之间找到联系，有时可能会颇具挑战性[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/7230432/aa334f9ad409/jcm-09-01011-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/7230432/aa334f9ad409/jcm-09-01011-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ec2/7230432/aa334f9ad409/jcm-09-01011-g001.jpg

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Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.短命非洲青鳉鱼大脑和肠球中核结合蛋白-2/nesfatin-1的个体发育模式变化
J Clin Med. 2019 Dec 31;9(1):103. doi: 10.3390/jcm9010103.
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Radiolabeled PET/MRI Nanoparticles for Tumor Imaging.用于肿瘤成像的放射性标记正电子发射断层扫描/磁共振成像纳米颗粒
J Clin Med. 2019 Dec 29;9(1):89. doi: 10.3390/jcm9010089.
3
The Mouse: A Translational Model of Human Neurological Conditions, or Simply a Good Tool for Better Understanding Neurodevelopment?
小鼠：人类神经疾病的转化模型，还是仅仅是更好理解神经发育的良好工具？
J Clin Med. 2019 Dec 1;8(12):2088. doi: 10.3390/jcm8122088.
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Bioengineered Skin Substitutes: the Role of Extracellular Matrix and Vascularization in the Healing of Deep Wounds.生物工程皮肤替代物：细胞外基质和血管生成在深度伤口愈合中的作用
J Clin Med. 2019 Dec 1;8(12):2083. doi: 10.3390/jcm8122083.
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Induced Pluripotent Stem Cells as Vasculature Forming Entities.诱导多能干细胞作为血管形成实体。
J Clin Med. 2019 Oct 25;8(11):1782. doi: 10.3390/jcm8111782.
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Human Red Blood Cells as Oxygen Carriers to Improve Ex-Situ Liver Perfusion in a Rat Model.人红细胞作为氧载体改善大鼠模型中的离体肝脏灌注
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Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs.构建用于生物工程组织和器官的无细胞和细胞负载支架的模块化策略。
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