Wu Xiaowei, Ding Shinn-Jyh, Lin Kaili, Su Jiansheng
Department of Prosthodontics, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China.
J Mater Chem B. 2017 May 7;5(17):3084-3102. doi: 10.1039/c6tb03067j. Epub 2017 Mar 24.
Tissue defects are usually caused by trauma, tumors, deformity, and infection. Use of tissue engineering technology to regenerate the defects, especially based on stem cells, has attracted widespread attention in recent years. To achieve faster healing and reconstruction of large scale defects, it is critically important to find scaffolds that are best for attachment and proliferation and can even induce the differentiation of stem cells. Recently, graphene and its derivatives have drawn significant attention due to their special physical and chemical properties, especially their biological properties. In this review, we summarized recent advances in tissue engineering based on graphene-family nanomaterials. For this purpose, a general description was provided to elucidate the biocompatibility, stimulation effects of graphene on cell differentiation, their potential applications in tissue regenerations, and the biodegradation property of the graphene-based materials. Moreover, the limitations and future trends of the applications of graphene in the biomedical field have been presented.
组织缺损通常由创伤、肿瘤、畸形和感染引起。近年来，利用组织工程技术来修复缺损，尤其是基于干细胞的技术，已引起广泛关注。为了实现大规模缺损的更快愈合和重建，找到最有利于细胞附着和增殖甚至能诱导干细胞分化的支架至关重要。最近，石墨烯及其衍生物因其特殊的物理和化学性质，尤其是生物学性质而备受关注。在本综述中，我们总结了基于石墨烯基纳米材料的组织工程的最新进展。为此，提供了一个总体描述，以阐明石墨烯的生物相容性、对细胞分化的刺激作用、它们在组织再生中的潜在应用以及基于石墨烯材料的生物降解特性。此外，还介绍了石墨烯在生物医学领域应用的局限性和未来趋势。
