Bobbert F S L, Zadpoor A A
Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, Delft 2628CD, The Netherlands.
J Mater Chem B. 2017 Aug 21;5(31):6175-6192. doi: 10.1039/c7tb00741h. Epub 2017 Jun 22.
The success of bone substitutes used to repair bone defects such as critical sized defects depends on the architecture of the porous biomaterial. The architectural parameters and surface properties affect cell seeding efficiency, cell response, angiogenesis, and eventually bone formation. The relevant parameters include pore size and porosity, pore shape and fibre orientation, surface properties, and mechanical properties. For example, small pores are preferable for cell seeding, but limit cell viability, cell proliferation and differentiation. Moreover, the pore size and geometry affect the alignment of cells and the structure of the regenerated bone. This paper presents an overview of the effects of porous biomaterial architecture including pore size and porosity, pore shape and fibre orientation, surface topography and chemistry, and structure stiffness on cell seeding efficiency, cell response, angiogenesis, and bone formation.
用于修复诸如临界尺寸骨缺损等骨缺损的骨替代物的成功取决于多孔生物材料的结构。结构参数和表面特性会影响细胞接种效率、细胞反应、血管生成以及最终的骨形成。相关参数包括孔径和孔隙率、孔形状和纤维取向、表面特性以及力学性能。例如，小孔有利于细胞接种，但会限制细胞活力、细胞增殖和分化。此外，孔径和几何形状会影响细胞排列以及再生骨的结构。本文概述了多孔生物材料结构，包括孔径和孔隙率、孔形状和纤维取向、表面形貌和化学性质以及结构刚度对细胞接种效率、细胞反应、血管生成和骨形成的影响。
