Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Cardiovasc Res. 2020 Oct 1;116(12):1932-1936. doi: 10.1093/cvr/cvaa093.
Angiotensin-converting enzyme 2 (ACE2) has emerged as a key regulator of the renin-angiotensin system in cardiovascular (CV) disease and plays a pivotal role in infections by coronaviruses and influenza viruses. The present review is primarily focused on the findings to indicate the role of ACE2 in the relationship of coronaviruses and influenza viruses to CV disease. It is postulated that the risk of coronavirus or influenza virus infection is high, at least partly due to high ACE2 expression in populations with a high CV risk. Coronavirus and influenza virus vaccine usage in high CV risk populations could be a potential strategy to prevent both CV disease and coronavirus/influenza virus infections.
血管紧张素转换酶 2（ACE2）已成为心血管疾病中肾素-血管紧张素系统的关键调节剂，在冠状病毒和流感病毒感染中发挥着关键作用。本综述主要侧重于发现，以表明 ACE2 在冠状病毒和流感病毒与心血管疾病的关系中的作用。据推测，由于高心血管风险人群中 ACE2 表达水平高，冠状病毒或流感病毒感染的风险很高。在高心血管风险人群中使用冠状病毒和流感病毒疫苗可能是预防心血管疾病和冠状病毒/流感病毒感染的一种潜在策略。
