Gupta Avinash N, Bhatti Amit A, Shah Mudasir M, Mahajan Niranjan P, Sadana Divya K, Huded Vikram
Department of Neurology, Narayana Institute of Neurosciences, Bengaluru, India.
Department of Neuropsychology, Narayana Institute of Neurosciences, Bengaluru, India.
Neurointervention. 2020 Jul;15(2):74-78. doi: 10.5469/neuroint.2020.00038. Epub 2020 Apr 9.
Carotid artery stenting (CAS) has evolved as a first-line therapeutic option for carotid revascularization in indicated patients for stroke prevention, but there is still a lack of data on its effect on cognitive function (CF), especially among Indian patients. To determine the effect of CAS on CF and to study the immediate and delayed complications of CAS in Indian patients.
This was a prospective, observational, single-center study. CF was assessed using Addenbrooke's cognitive examination version III (ACE) before and 3 months after stenting. The demographic and clinical parameters were also assessed. A follow-up evaluation after 3 months was done to compare CF and to observe the occurrence of any complications.
Out of 31 patients, 3 were lost to follow up. There were no immediate or delayed procedure-related complications. There was a statistically significant improvement in overall ACE score and memory before and after stenting. On subgroup analysis of those with and without strokes, there was a significant improvement in visuospatial function and mean ACE score. Those with left CAS had significant improvement in memory, visuospatial, language, and ACE scores than right CAS.
CAS was associated with significant improvement in CF in patients.
对于有卒中预防指征的患者，颈动脉支架置入术（CAS）已发展成为颈动脉血运重建的一线治疗选择，但关于其对认知功能（CF）影响的数据仍然缺乏，尤其是在印度患者中。本研究旨在确定CAS对CF的影响，并研究印度患者CAS的即刻和延迟并发症。
这是一项前瞻性、观察性、单中心研究。在支架置入术前和术后3个月使用Addenbrooke认知检查第三版（ACE）评估CF。同时评估人口统计学和临床参数。3个月后进行随访评估，以比较CF并观察是否发生任何并发症。
31例患者中，3例失访。未发生与手术相关的即刻或延迟并发症。支架置入术前和术后总体ACE评分和记忆力有统计学显著改善。在有或无卒中患者的亚组分析中，视觉空间功能和平均ACE评分有显著改善。左颈动脉支架置入术患者在记忆力、视觉空间、语言和ACE评分方面比右颈动脉支架置入术患者有显著改善。
CAS与患者CF的显著改善相关。
