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1
Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses.治疗后莱姆病综合征：由适应性不良的宿主反应引起的独特发病机制。
J Clin Invest. 2020 May 1;130(5):2148-2151. doi: 10.1172/JCI138062.
2
Lyme neuroborreliosis.莱姆病性神经伯氏疏螺旋体病
Curr Opin Neurol. 1998 Jun;11(3):253-8. doi: 10.1097/00019052-199806000-00011.
3
Clinical manifestations and epidemiological characteristics of Lyme disease in Hailin county, Heilongjiang Province, China.中国黑龙江省海林市莱姆病的临床表现及流行病学特征
Ann N Y Acad Sci. 1988;539:302-13. doi: 10.1111/j.1749-6632.1988.tb31864.x.
4
[Lyme disease and Borrelia burgdorferi infections in Europe].[欧洲的莱姆病与伯氏疏螺旋体感染]
Ann Biol Clin (Paris). 1989;47(7):428-37.
5
Lyme disease.莱姆病
Curr Opin Rheumatol. 1995 Jul;7(4):322-8. doi: 10.1097/00002281-199507000-00010.
6
Distribution and presentation of Lyme borreliosis in Scotland - analysis of data from a national testing laboratory.苏格兰莱姆病疏螺旋体病的分布与表现——来自国家检测实验室的数据分析
J R Coll Physicians Edinb. 2015;45(3):196-200. doi: 10.4997/JRCPE.2015.304.
7
Lyme arthritis in European children and adolescents. The Pediatric Rheumatology Collaborative Group.欧洲儿童和青少年的莱姆关节炎。儿科风湿病协作组。
Arthritis Rheum. 1995 Mar;38(3):361-8. doi: 10.1002/art.1780380310.
8
[Lyme arthritis, Lyme carditis and other presentations potentially associated to Lyme disease].[莱姆关节炎、莱姆心肌炎及其他可能与莱姆病相关的表现]
Med Mal Infect. 2007 Jul-Aug;37(7-8):422-34. doi: 10.1016/j.medmal.2006.01.026. Epub 2007 Aug 14.
9
Lyme disease in children.儿童莱姆病
Semin Neurol. 1997 Mar;17(1):39-44. doi: 10.1055/s-2008-1040911.
10
[Lyme arthritis].[莱姆关节炎]
Przegl Lek. 2007;64(2):111-4.

引用本文的文献

1
The peptidoglycan of can persist in discrete tissues and cause systemic responses consistent with chronic illness.[此处原文中“of”后缺少具体内容]的肽聚糖可在离散组织中持续存在，并引发与慢性病一致的全身反应。
Sci Transl Med. 2025 Apr 23;17(795):eadr2955. doi: 10.1126/scitranslmed.adr2955.
2
Bridging the gap: Insights in the immunopathology of Lyme borreliosis.弥合差距：莱姆病免疫病理学的见解
Eur J Immunol. 2024 Dec;54(12):e2451063. doi: 10.1002/eji.202451063. Epub 2024 Oct 13.
3
Current and emerging approaches for eliminating and alleviating persistent Lyme disease symptoms.消除和缓解莱姆病持续症状的现有及新出现的方法。
Front Microbiol. 2024 Sep 13;15:1459202. doi: 10.3389/fmicb.2024.1459202. eCollection 2024.
4
Identification of Major Histocompatibility Complex Class II Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia burgdorferi Mcp4 in Murine Lyme Arthritis.从莱姆病自身抗原载脂蛋白 B-100 和伯氏疏螺旋体 Mcp4 中鉴定主要组织相容性复合体 II 表位在鼠莱姆关节炎中的作用。
J Infect Dis. 2024 Aug 14;230(Supplement_1):S27-S39. doi: 10.1093/infdis/jiae324.
5
Insights From Omics in Lyme Disease.从组学角度看莱姆病
J Infect Dis. 2024 Aug 14;230(Supplement_1):S18-S26. doi: 10.1093/infdis/jiae250.
6
Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation.伯氏疏螺旋体在巨噬细胞中启动早期转录重编程，从而支持长期抑制炎症。
PLoS Pathog. 2023 Dec 29;19(12):e1011886. doi: 10.1371/journal.ppat.1011886. eCollection 2023 Dec.
7
Diagnostic probability classification in suspected borreliosis by a novel C6-peptide IgG1- subclass antibody test.新型 C6-肽 IgG1 亚类抗体检测在疑似莱姆病中的诊断概率分类。
Front Cell Infect Microbiol. 2023 Sep 11;13:1108115. doi: 10.3389/fcimb.2023.1108115. eCollection 2023.
8
Lyme Disease: An Overview.莱姆病概述
Indian Dermatol Online J. 2023 Feb 23;14(5):594-604. doi: 10.4103/idoj.idoj_418_22. eCollection 2023 Sep-Oct.
9
Development of an mRNA-lipid nanoparticle vaccine against Lyme disease.针对莱姆病的 mRNA-脂质纳米颗粒疫苗的研制。
Mol Ther. 2023 Sep 6;31(9):2702-2714. doi: 10.1016/j.ymthe.2023.07.022. Epub 2023 Aug 2.
10
The Interaction of Borrelia burgdorferi with Human Dendritic Cells: Functional Implications.伯氏疏螺旋体与人树突状细胞的相互作用：功能意义。
J Immunol. 2023 Aug 15;211(4):612-625. doi: 10.4049/jimmunol.2300235.

本文引用的文献

1
A Review of Antibiotic-Tolerant Persisters and Their Relevance to Posttreatment Lyme Disease Symptoms.抗生素耐受持久体及其与治疗后莱姆病症状相关性的综述。
Am J Med. 2020 Apr;133(4):429-431. doi: 10.1016/j.amjmed.2019.12.007. Epub 2020 Jan 9.
2
peptidoglycan is a persistent antigen in patients with Lyme arthritis.肽聚糖是莱姆关节炎患者的一种持续存在的抗原。
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13498-13507. doi: 10.1073/pnas.1904170116. Epub 2019 Jun 17.
3
Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure.伯氏疏螺旋体的稳定期持留菌/生物膜微菌落会在莱姆关节炎小鼠模型中引发更严重的疾病：对理解细菌持留、治疗后莱姆病综合征（PTLDS）及治疗失败的启示
Discov Med. 2019 Mar;27(148):125-138.
4
Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells.在莱姆关节炎滑膜组织中产生的干扰素-γ促进成纤维样滑膜细胞向免疫效应细胞分化。
Cell Microbiol. 2019 Feb;21(2):e12992. doi: 10.1111/cmi.12992. Epub 2019 Jan 4.
5
Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis.感染后伯氏疏螺旋体诱导的莱姆关节炎患者滑膜组织中干扰素信号稳健且组织修复基因表达受抑。
Cell Microbiol. 2019 Feb;21(2):e12954. doi: 10.1111/cmi.12954. Epub 2018 Oct 17.
6
Long-term use of antibiotics and risk of colorectal adenoma.长期使用抗生素与结直肠腺瘤风险的关系。
Gut. 2018 Apr;67(4):672-678. doi: 10.1136/gutjnl-2016-313413. Epub 2017 Apr 4.
7
MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis.微小 RNA 表达显示感染后莱姆关节炎患者关节中的炎症失调和类似肿瘤的增殖反应。
Arthritis Rheumatol. 2017 May;69(5):1100-1110. doi: 10.1002/art.40039.
8
Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthritis Following Lyme Disease.莱姆病后的自身免疫性关节炎、类风湿关节炎、银屑病关节炎或外周脊柱关节炎。
Arthritis Rheumatol. 2017 Jan;69(1):194-202. doi: 10.1002/art.39866.
9
CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease Syndrome: a Prospective Clinical Cohort Study.CCL19作为治疗后莱姆病综合征的趋化因子危险因素：一项前瞻性临床队列研究。
Clin Vaccine Immunol. 2016 Sep 6;23(9):757-66. doi: 10.1128/CVI.00071-16. Print 2016 Sep.
10
Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease.随机试验：更长时间治疗莱姆病相关症状的疗效。
N Engl J Med. 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425.

Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses.

作者信息

Steere Allen C

出版信息

J Clin Invest. 2020 May 1;130(5):2148-2151. doi: 10.1172/JCI138062.

DOI:10.1172/JCI138062
PMID:32281948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7190968/
Abstract
摘要