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法医学中的组学时代:迈向新纪元。

Omics era in forensic medicine: towards a new age.

机构信息

Department of Forensic Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Department of Forensic Medicine, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

出版信息

Turk J Med Sci. 2020 Aug 26;50(5):1480-1490. doi: 10.3906/sag-1912-197.

Abstract

BACKGROUND/AIM: Forensic medicine and sciences is a multidisciplinary branch of science, which frequently benefit from novel technologies. State of the art omics technologies have begun to be performed in forensic medicine and sciences, particularly in postmortem interval, intoxication, drugs of abuse, diagnosis of diseases and cause of death. This review aims to discuss the role and use of great omics (metabolomics, proteomics, genomics and transcriptomics) in forensic sciences, in detail.

MATERIALS AND METHODS

A detailed review of related literature was performed, and studies were subdivided as per the type of omics.

RESULTS AND CONCLUSION

Omics seems as a revolutionary step in forensic science and sure carries it towards a new age. The number of forensic studies utilizing omics steadily increases in last years. Omics strategies should be used together in order to gather more accurate and certain data. Additional studies need to be performed to incorporate omics into routine forensic methodology.

摘要

背景/目的:法医学和科学是一门多学科的科学分支,经常受益于新技术。最先进的组学技术已经开始在法医学和科学中进行,特别是在死后间隔时间、中毒、滥用药物、疾病诊断和死因方面。本综述旨在详细讨论组学(代谢组学、蛋白质组学、基因组学和转录组学)在法医学中的作用和应用。

材料和方法

对相关文献进行了详细的回顾,并根据组学的类型对研究进行了细分。

结果与结论

组学似乎是法医学的一个革命性步骤,肯定将其带入了一个新时代。近年来,利用组学进行的法医研究数量稳步增加。为了收集更准确和确定的数据,应该一起使用组学策略。需要进行更多的研究将组学纳入常规法医方法中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1e/7491271/7c41d1fb5e02/turkjmedsci-50-1480-fig001.jpg

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