Dawidowska Joanna, Krzyżanowska Marta, Markuszewski Michał Jan, Kaliszan Michał
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Department of Forensic Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Metabolites. 2021 Nov 26;11(12):801. doi: 10.3390/metabo11120801.
Recently, the diagnostic methods used by scientists in forensic examinations have enormously expanded. Metabolomics provides an important contribution to analytical method development. The main purpose of this review was to investigate and summarize the most recent applications of metabolomics in forensic science. The primary research method was an extensive review of available international literature in PubMed. The keywords "forensic" and "metabolomics" were used as search criteria for the PubMed database scan. Most authors emphasized the analysis of different biological sample types using chromatography methods. The presented review is a summary of recently published implementations of metabolomics in forensic science and types of biological material used and techniques applied. Possible opportunities for valuable metabolomics' applications are discussed to emphasize the essential necessities resulting in numerous nontargeted metabolomics' assays.
最近，科学家们在法医检验中使用的诊断方法有了极大的扩展。代谢组学为分析方法的发展做出了重要贡献。本综述的主要目的是研究和总结代谢组学在法医学中的最新应用。主要研究方法是广泛查阅PubMed上的国际文献。关键词“法医”和“代谢组学”被用作PubMed数据库扫描的搜索标准。大多数作者强调使用色谱方法分析不同类型的生物样本。本综述总结了代谢组学在法医学中最近发表的应用实例、所使用的生物材料类型和应用的技术。讨论了代谢组学有价值应用的可能机会，以强调导致众多非靶向代谢组学分析的基本需求。
