Che Yingying, Fu Lin
Institute of Chronic Disease, Qingdao Municipal Hospital, Qingdao University, Qingdao 266000, China.
J Cancer. 2020 Mar 15;11(12):3502-3511. doi: 10.7150/jca.42645. eCollection 2020.
Alternative splicing facilitates the splicing of precursor RNA into different isoforms. Alternatively spliced transcripts often exhibit antagonistic functions or differential temporal or spatial expression patterns. There is increasing evidence that alternative splicing, especially by the serine-arginine rich (SR) protein family, leads to abnormal expression patterns and is closely related to the development of cancer. SRSF3, also known as SRp20, is a splicing factor. Through alternative splicing, it plays important roles in regulating various biological functions, such as cell cycle, cell proliferation, migration and invasion, under pathological and physiological conditions. Deregulation of SRSF3 is an essential feature of cancers. SRSF3 is also considered a candidate therapeutic target. Therefore, the involvement of abnormal splicing in tumorigenesis and the regulation of splicing factors deserve further analysis and discussion. Here, we summarize the function of SRSF3-regulated alternative transcripts in cancer cell biology at different stages of tumor development and the regulation of SRSF3 in tumorigenesis.
可变剪接有助于将前体RNA剪接成不同的异构体。可变剪接的转录本通常表现出拮抗功能或不同的时空表达模式。越来越多的证据表明，可变剪接，尤其是富含丝氨酸-精氨酸（SR）的蛋白质家族介导的可变剪接，会导致异常的表达模式，并且与癌症的发生密切相关。SRSF3，也称为SRp20，是一种剪接因子。通过可变剪接，它在病理和生理条件下调节各种生物学功能，如细胞周期、细胞增殖、迁移和侵袭等方面发挥重要作用。SRSF3失调是癌症的一个重要特征。SRSF3也被认为是一个候选治疗靶点。因此，异常剪接在肿瘤发生中的作用以及剪接因子的调控值得进一步分析和讨论。在这里，我们总结了SRSF3调控的可变转录本在肿瘤发展不同阶段的癌细胞生物学中的功能以及SRSF3在肿瘤发生中的调控作用。
