Gao Chen, Li Jiaying, Wu Linyu, Kong Dexing, Xu Maosheng, Zhou Changyu
The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Front Oncol. 2020 Mar 27;10:318. doi: 10.3389/fonc.2020.00318. eCollection 2020.
The detection rate for pulmonary nodules, particularly subsolid nodules (SSNs), has been significantly improved. The purpose of this review is to summarize the relationship between quantitative features of initial CT imaging and the subsequent natural growth of SSNs to explore potential reasons for these findings. Relevant studies were collected from a literature search of PubMed, Embase, Web of Science, and Cochrane. Data extraction was performed on the patients' basic information, CT methods, and acquisition methods, including quantitative CT features, and statistical methods. A total of 10 relevant articles were included in our review, which included 850 patients with 1,026 SSNs. Overall, the results were variable, and the key findings were as follows. Seven studies looked at the relationship between the diameter and growth of SSNs, showing that SSNs with larger diameters were associated with increased growth. An additional three studies which focused on the relationship between CT attenuation and the growth of SSNs showed that SSNs with a high CT attenuation were associated with increased growth. CT attenuation may be useful in predicting the natural growth of SSNs, and mean CT attenuation may be more useful in predicting the natural growth of pure ground glass nodules (GGNs) than part-solid GGNs. While evaluation by diameter did have some limitations, it demonstrates value in predicting the growth of SSNs.
肺结节，尤其是亚实性结节（SSN）的检出率有了显著提高。本综述的目的是总结初始CT影像的定量特征与SSN后续自然生长之间的关系，以探究这些结果的潜在原因。通过对PubMed、Embase、Web of Science和Cochrane进行文献检索收集相关研究。对患者的基本信息、CT方法和采集方法进行数据提取，包括CT定量特征和统计方法。我们的综述共纳入10篇相关文章，其中包括850例患者的1026个SSN。总体而言，结果各不相同，主要发现如下。七项研究探讨了SSN直径与生长之间的关系，结果表明直径较大的SSN生长增加。另外三项关注CT衰减与SSN生长关系的研究表明，CT衰减较高的SSN生长增加。CT衰减可能有助于预测SSN的自然生长，平均CT衰减在预测纯磨玻璃结节（GGN）的自然生长方面可能比部分实性GGN更有用。虽然通过直径进行评估确实存在一些局限性，但它在预测SSN生长方面具有一定价值。
