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美沙拉嗪衍生物的细胞毒性 Ru-p-柠檬烯配合物对 3D 结肠癌干细胞球的抑制作用。

Inhibition of 3D colon cancer stem cell spheroids by cytotoxic Ru-p-cymene complexes of mesalazine derivatives.

机构信息

Department of Chemical Sciences and Centre for Advance Functional Materials (CAFM), Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal 741246, India.

National Institute of Biomedical and Genomics, Kalyani, West Bengal 741251, India.

出版信息

Chem Commun (Camb). 2020 May 19;56(40):5421-5424. doi: 10.1039/d0cc00472c.

DOI:10.1039/d0cc00472c
PMID:32292957
Abstract

The Ru(ii) complex of an imidazole-mesalazine Schiff base is a unique example showing growth inhibition of 3D-colon cancer stem cell spheroids and bulk colon cancer cells at lower dosage than salinomycin or oxaliplatin. Unlike oxaliplatin which increases the expression of stemness genes (SOX2, KLF4, HES1 and Oct4), these complexes maintain a tight regulation.

摘要

咪唑-美沙拉嗪希夫碱的 Ru(ii) 配合物是一个独特的例子，它在较低剂量下显示出对 3D 结肠癌细胞球和大块结肠癌细胞的生长抑制作用，低于萨利霉素或奥沙利铂。与增加干性基因（SOX2、KLF4、HES1 和 Oct4）表达的奥沙利铂不同，这些配合物保持严格的调控。

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