Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland.
Department of Internal Diseases, Occupational Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland.
PLoS One. 2020 Apr 16;15(4):e0231076. doi: 10.1371/journal.pone.0231076. eCollection 2020.
475 patients (including 222 women), mean age 69.7±7.7, with HF, hospitalized at University Hospital between January and December 2018 were included in the study. The patients were selected by a physician specializing in cardiology. A cardiac nurse assessed the non-pharmacological level of compliance using the Revised Heart Failure Compliance Questionnaire (RHFCQ). The socio-clinical data were obtained from medical records. The majority of the study group were patients in NYHA II (62.4%) and NYHA III (28.3%), the mean duration of the disease was 6.2±4.9 years, and the mean ejection fraction of the left ventricle (EF) was 48.6±12.6. The average level of compliance in the study group measured on a scale from 0 to 4 points was: median = 2.7, IQR [2.32; 3.25]. Only 6.9% of the respondents adhere to recommendations totally (all dimensions of RHFCQ). In univariate analysis, predictors negatively affecting compliance were: female gender (rho = -0.325), age below 65 years (rho = -0.014)), loneliness (rho = -0.559), number of hospitalizations (rho = -0.242), higher stage of NYHA (rho = -1.612), co-morbidities (rho = -0.729), re-hospitalizations (rho = -0.729), beta-blockers treatment (rho = -1.612) and diuretics treatment (rho = -0.276). Factors positively affecting compliance were: EF≥45% (rho = 0.020) and treatment with ACEI/ARB (rho = 0.34), whereas compliance was negatively affected by-EF<45% (β = 0.009). Independent predictors influencing the level of compliance were: loneliness (β = -1.816), number of hospitalizations (β = -0.117), NYHA III and IV and number of co-morbidities (β = -0.676).
Patients with HF do not adhere to therapeutic recommendations. The lowest compliance levels were found for exercise and daily weighing, and the highest for follow-up appointment-keeping and medication. Loneliness and age are the strongest predictors which influence the level of compliance.
本研究共纳入 2018 年 1 月至 12 月期间在大学医院因心衰住院的 475 例患者(包括 222 名女性),平均年龄为 69.7±7.7 岁。入选标准由心内科医师确定。一名心脏科护士使用修订版心衰依从性问卷(RHFCQ)评估非药物治疗的依从性。社会临床数据来自病历。研究组大多数患者为纽约心功能分级(NYHA)Ⅱ级(62.4%)和 NYHA Ⅲ级(28.3%),疾病平均病程为 6.2±4.9 年,左心室射血分数(EF)平均为 48.6±12.6。研究组在 0 到 4 分的评分量表上的平均依从性水平为:中位数=2.7,IQR[2.32;3.25]。仅有 6.9%的受访者完全遵守建议(RHFCQ 的所有维度)。单因素分析显示,依从性的负性预测因素为:女性(rho=-0.325)、年龄<65 岁(rho=-0.014)、孤独(rho=-0.559)、住院次数(rho=-0.242)、更高的 NYHA 分级(rho=-1.612)、合并症(rho=-0.729)、再住院(rho=-0.729)、β受体阻滞剂治疗(rho=-1.612)和利尿剂治疗(rho=-0.276)。依从性的正性预测因素为:EF≥45%(rho=0.020)和 ACEI/ARB 治疗(rho=0.34),而 EF<45%(β=0.009)则会降低依从性。影响依从性水平的独立预测因素为:孤独(β=-1.816)、住院次数(β=-0.117)、NYHA Ⅲ和Ⅳ级和合并症数量(β=-0.676)。
心衰患者不遵守治疗建议。运动和每日称重的依从性最低,而随访预约和药物治疗的依从性最高。孤独和年龄是影响依从性水平的最强预测因素。