Food & Health Lab, Institute of Materials Science, University of Valencia, 46980 Paterna, Valencia, Spain.
Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, 46021 Valencia, Spain.
Nutrients. 2020 Apr 19;12(4):1143. doi: 10.3390/nu12041143.
For millennia, naturopaths and physicians have used (reishi mushroom) for its diverse therapeutic properties, as recorded in the oldest Chinese herbal encyclopedia. Indeed, a radioprotective effect has been reported in the isolated components of its extracts. A systematic review and meta-analyses (PRISMA) was conducted in March 2020, searching databases including PubMed, Scopus, Embase, and Google Scholar, along with Clinical Trials. The inclusion criteria were ex vivo, in vitro, and in vivo studies, with full texts in English, conducted to determine the radioprotective benefits of , or reports in which ionizing radiation was used. From a total number of 1109 records identified, 15 full text articles were eligible, none of them were clinical trials. In vivo studies reveal the efficiency of aqueous extracts of polysaccharides and triterpenes in mice exposed to -rays. In plasmid, they can reduce radiation damage as an increment of the open circular form, as well as increase the DNA extension, as shown in vitro studies. Ex vivo studies conducted in human blood cells show the radioprotective effect of β-glucan of aqueous extract of , nevertheless, its implementation as radioprotector to humans is in need of further clinical research studies.
千百年来，灵芝（reishi mushroom）因其多种治疗特性而被顺势疗法医生和内科医生使用，这在最早的中国草药百科全书中有记载。事实上，其提取物的分离成分已被报道具有放射防护作用。2020 年 3 月进行了系统评价和荟萃分析（PRISMA），在 PubMed、Scopus、Embase 和 Google Scholar 等数据库中进行了检索，并结合临床试验进行了检索。纳入标准为离体、体外和体内研究，全文为英文，旨在确定灵芝的放射防护益处，或报告中使用了电离辐射。在总共确定的 1109 条记录中，有 15 篇全文文章符合条件，没有一篇是临床试验。体内研究表明，灵芝多糖和三萜类化合物的水提物在接受射线照射的小鼠中具有效率。在质粒中，它们可以减少辐射损伤，增加开环形式的数量，以及增加 DNA 的延伸，如体外研究所示。在人类血细胞中进行的离体研究表明，灵芝水提物β-葡聚糖具有放射防护作用，然而，将其作为放射保护剂应用于人类还需要进一步的临床研究。
