暴露组学有何新特点？探索当代流行病学中的科学变革。
What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology.
机构信息
Institute of Philosophy, Leibniz University Hannover, Im Moore 21, 30167 Hannover, Germany.
出版信息
Int J Environ Res Public Health. 2020 Apr 22;17(8):2879. doi: 10.3390/ijerph17082879.
In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been conceived, developed and established in the context of contemporary epidemiological research. I argue that the exposome has been developed by transferring approaches, methods and conceptualizations from other lines of research in the life and health sciences. I thus discuss the conceptual and methodological innovations of the exposome as a result of the merging and adaptation of these elements for new uses and purposes. On this basis, I argue that the novelty of the exposome should be seen in incremental rather than revolutionary terms and, in this sense, the exposome shares significant elements with other projects and repertoires in postgenomics. I conclude by discussing the consequences of this analysis for the potential limitations and future development of exposome research.
在这篇评论中，我讨论了外显子组带来的科学变革，探讨了这种方法和研究路线的新颖之处。我通过分析外显子组在当代流行病学研究背景下的构思、发展和确立条件，将其置于历史视角下。我认为，外显子组是通过将来自生命和健康科学其他研究领域的方法、手段和概念转移过来而发展起来的。因此，我讨论了外显子组作为这些元素融合和适应新用途和目的的结果的概念和方法上的创新。在此基础上，我认为外显子组的新颖性应该从增量而不是革命性的角度来看待，从这个意义上说，外显子组与后基因组学中的其他项目和方案有很大的共同之处。最后，我讨论了这一分析对外显子组研究的潜在局限性和未来发展的影响。
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