Monte Carlo simulation of digital photon counting PET.

A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NEMA guidelines. Comparisons were performed using listmode data in order to remain independent of image reconstruction algorithms. An original line of response-based method is proposed to estimate intrinsic spatial resolution without reconstruction. Four sets of experiments were performed: (1) count rates and scatter fraction, (2) energy and timing resolutions, (3) sensitivity, and (4) intrinsic spatial resolution. Experimental and simulated data were found to be in good agreement, with overall differences lower than 10% for activity concentrations used in most standard clinical applications. Illustrative image reconstructions were provided. In conclusion, the proposed Monte Carlo model was validated and can be used for numerous studies such as optimizing acquisition parameters or reconstruction algorithms.