对L-谷氨酸、L-酪氨酸和L-丙氨酸共聚物的IgG类主要应答的限制以及IgM应答对二次免疫的依赖性。
Restriction of primary responses to the IgG class and dependency of IgM responses on secondary immunization for the copolymers of L-glutamic acid, L-tyrosine, and L-alanine.
作者信息
Waltenbaugh C, Thèze J, Benacerraf B
出版信息
J Exp Med. 1977 May 1;145(5):1278-87. doi: 10.1084/jem.145.5.1278.
Abstract
Primary responses to the linear polymers of L-glutamic acid, L-tyrosine, and L-alanine are restricted to the IgG class of antibodies. The appearance of specific IgM antibodies against these antigens is dependent upon secondary immunization, in contrast to many classical antigenic systems. The presence of an IgM response was verified by a direct plaque-forming cell assay, the inhibition of direct plaques by an antiserum specific for mouse micron-chain, and the physical separation of IgM and IgG GAT-specific antibodies by gel filtration. Preimmunization of the appropriate nonresponder strain with GAT or GT inhibits both the secondary IgM and IgG responses to GAT-MBSA and GT-MBSA, respectively. The tolerance observed is due to the induction of suppressor cells as demonstrated by cell transfer experiments.
摘要
对L-谷氨酸、L-酪氨酸和L-丙氨酸线性聚合物的初次反应仅限于IgG类抗体。与许多经典抗原系统不同，针对这些抗原的特异性IgM抗体的出现依赖于二次免疫。通过直接空斑形成细胞试验、用小鼠μ链特异性抗血清抑制直接空斑以及通过凝胶过滤对IgM和IgG GAT特异性抗体进行物理分离，证实了IgM反应的存在。用GAT或GT对适当的无反应品系进行预免疫，分别抑制了对GAT-MBSA和GT-MBSA的二次IgM和IgG反应。如细胞转移实验所示，观察到的耐受性是由于抑制细胞的诱导。
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