Zhang Heng, Zhan Danting, Chen Dandan, Huang Weibin, Yu Min, Li Qiuwen, Marcos Pedro J, Tattevin Pierre, Wu Di, Wang Lingwei
Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen Institute of Respiratory Diseases, Shenzhen Key Laboratory of Respiratory Diseases, Shenzhen 518020, China.
Pneumology Service, Institute of Biomedical Research of A Coruña (INIBIC), University Hospital Complex of A Coruña (CHUAC), Universidade da Coruna (UDC), A Coruña, Spain.
Ann Transl Med. 2020 Mar;8(6):401. doi: 10.21037/atm.2020.03.17.
This study includes a retrospective analysis of the diagnosis and treatment of a case of severe pneumonia from fulminant psittacosis with multiple organ failure. Next-generation sequencing (NGS) of the pathogen was conducted. The purpose of this study was to summarize the clinical, laboratory, and imaging characteristics of the case and to improve understanding of the value of NGS in the diagnosis of severe community-acquired pneumonia (CAP). Fulminant psittacosis can be manifested as severe pneumonia with rapid progression, acute respiratory distress syndrome, sepsis, and multiple organ failure. Imaging shows unilateral lung consolidation, which is difficult to differentiate from CAP caused by common pathogens. The NGS technology can early detect rare pathogens, thus reducing unnecessary use of antibiotics and shortening the course of the disease.
本研究包括对1例暴发性鹦鹉热伴多器官衰竭所致重症肺炎的诊断和治疗进行回顾性分析。对病原体进行了二代测序（NGS）。本研究的目的是总结该病例的临床、实验室和影像学特征，并提高对NGS在重症社区获得性肺炎（CAP）诊断中价值的认识。暴发性鹦鹉热可表现为进展迅速的重症肺炎、急性呼吸窘迫综合征、脓毒症和多器官衰竭。影像学表现为单侧肺实变，难以与常见病原体所致的CAP相鉴别。NGS技术可早期检测出罕见病原体，从而减少抗生素的不必要使用并缩短病程。
