Department of Dermatology and Venerology, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, China.
Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
BMC Cancer. 2020 May 5;20(1):378. doi: 10.1186/s12885-020-06849-7.
Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on immune infiltrates and whether it associates with survival of SKCM and SKCM-metastasis patients has not been explored.
We evaluated SRGN expression via the databases of Oncomine, Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA). The influence of SRGN expression on survival of SKCM and SKCM-metastasis patients was analyzed using TIMER database. Furthermore, the correlations between SRGN expression and immune infiltrates or gene marker sets of immune infiltrates were also analyzed via TIMER database.
We found that the expression of SRGN in SKCM and SKCM-metastasis tissues was significantly increased compared to the normal skin tissues (P < 0.001). Interestingly, it was showed that lower level of SRGN expression and lower immune infiltrates of B cell, CD8+ T cell, Neutrophil, and Dendritic cell were correlated with poor survival rate of SKCM and SKCM-metastasis patients (P < 0.001) but not SKCM primary patients. We also demonstrated that SRGN expression was positively associated with the immune infiltrates and diverse immune marker sets in SKCM and SKCM-metastasis.
Our findings indicated that SRGN was associated with the survival of SKCM and SKCM-metastasis patients. SRGN may be a new immune therapy target for treating SKCM and SKCM-metastasis.
皮肤黑色素瘤（SKCM）是全球最具侵袭性的癌症之一。硫酸角质素（SRGN）是一种细胞内蛋白聚糖，在各种肿瘤中发挥着重要作用。然而，它对免疫浸润的影响以及它是否与 SKCM 和 SKCM 转移患者的生存相关尚未被探索。
我们通过 Oncomine、肿瘤免疫估计资源（TIMER）和基因表达谱交互式分析（GEPIA）数据库评估了 SRGN 的表达。使用 TIMER 数据库分析了 SRGN 表达对 SKCM 和 SKCM 转移患者生存的影响。此外，还通过 TIMER 数据库分析了 SRGN 表达与免疫浸润或免疫浸润基因标志物集之间的相关性。
我们发现，与正常皮肤组织相比，SKCM 和 SKCM 转移组织中的 SRGN 表达明显增加（P < 0.001）。有趣的是，结果表明，SRGN 表达水平较低且 B 细胞、CD8+T 细胞、中性粒细胞和树突状细胞的免疫浸润较低与 SKCM 和 SKCM 转移患者的生存率较差相关（P < 0.001），但与 SKCM 原发性患者无关。我们还表明，SRGN 表达与 SKCM 和 SKCM 转移中的免疫浸润和不同的免疫标志物集呈正相关。
我们的研究结果表明，SRGN 与 SKCM 和 SKCM 转移患者的生存相关。SRGN 可能成为治疗 SKCM 和 SKCM 转移的新的免疫治疗靶点。
