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玛格丽奥可多切甜红葡萄酒及其果渣提取物的血管舒张作用

Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce .

作者信息

Carullo Gabriele, Ahmed Amer, Fusi Fabio, Sciubba Fabio, Di Cocco Maria Enrica, Restuccia Donatella, Spizzirri Umile Gianfranco, Saponara Simona, Aiello Francesca

机构信息

Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Ed. Polifunzionale, 87036 Rende (CS), Italy.

Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

出版信息

Pharmaceuticals (Basel). 2020 May 3;13(5):87. doi: 10.3390/ph13050087.

DOI:10.3390/ph13050087
PMID:32375256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7281491/
Abstract

Several epidemiological studies demonstrate that moderate (red) wine consumption may afford protection against cardiovascular diseases. Protection is ascribed to the biological activity of wine components, many of which, however, are discarded during winemaking. In vitro rat thoracic aorta rings contracted with phenylephrine or KCl were used to assess the vasorelaxant activity of extracts from wine pomaces (seeds and skins) of the Calabrian autochthonous grape variety Magliocco dolce (Arvino). NMR spectroscopy was used to ascertain their chemical composition. Data demonstrate that seed and skin, but not must, extracts are capable of relaxing vascular preparations in an endothelium-dependent manner, similarly to the red wine extract, due to the presence of comparable amounts of bioactive constituents. In rings pre-contracted with 20-30 mM KCl, only seed extracts showed a moderate relaxation. The most efficacious vasodilating extract (wine) showed a good antioxidant profile in both [(2,2-diphenyl-1-picrylhydrazyl)acid] radical (DPPH) and [2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] radical (ABTS) assays. In conclusion, winemaking from Magliocco dolce grape can provide potentially health-promoting by-products useful in cardiovascular disease management.

摘要

多项流行病学研究表明，适量饮用（红）葡萄酒可能对心血管疾病具有预防作用。这种保护作用归因于葡萄酒成分的生物活性，然而，其中许多成分在酿酒过程中被丢弃。使用苯肾上腺素或氯化钾收缩的体外大鼠胸主动脉环来评估卡拉布里亚本土葡萄品种马利奥科多切（阿尔维诺）的葡萄皮渣（种子和果皮）提取物的血管舒张活性。核磁共振光谱用于确定其化学成分。数据表明，种子和果皮提取物而非葡萄汁提取物能够以内皮依赖性方式舒张血管制剂，这与红酒提取物类似，因为它们含有相当数量的生物活性成分。在预先用20 - 30 mM氯化钾收缩的血管环中，只有种子提取物表现出适度的舒张作用。在2,2 - 二苯基 - 1 - 苦基肼自由基（DPPH）和2,2'- 偶氮二（3 - 乙基苯并噻唑啉 - 6 - 磺酸）自由基（ABTS）测定中，最有效的血管舒张提取物（葡萄酒）显示出良好的抗氧化特性。总之，用马利奥科多切葡萄酿酒可以提供潜在的有益健康的副产品，有助于心血管疾病的管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cb/7281491/46533ce0bf35/pharmaceuticals-13-00087-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cb/7281491/e8b35a7e551b/pharmaceuticals-13-00087-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cb/7281491/a06289a1873d/pharmaceuticals-13-00087-g003.jpg
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