mA Editing: New Tool to Improve Crop Quality?

N-methyladenosine (mA) is the most common type of eukaryotic mRNA modification. It plays an important role in regulating plant growth and development and stress resistance. mA modification influences nearly all aspects of RNA metabolism and functionality and has great potential for improving crop quality. However, changing mA modification levels as a whole may have unpredictable effects, making it impossible to accurately predict the effect of specific mA modifications on RNA. In this opinion article, the main challenges and possible solutions for exploring mA modification functions in plant systems are discussed. An mA editing platform that uses new high-throughput methods to identify mA modification at single-base resolution, and genome editing for selective editing of specific mA sites for crop improvement is proposed.