Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Inje University College of Medicine, Busan, Korea.
PLoS One. 2020 May 11;15(5):e0232135. doi: 10.1371/journal.pone.0232135. eCollection 2020.
Postural dysfunction is one of the most common community health symptoms and frequent chief complaints in hospitals. Sarcopenia is a syndrome characterized by degenerative loss of skeletal muscle mass, muscle quality, and muscle strength, and is the main contributor to musculoskeletal impairment in the elderly. Previous studies reported that loss of muscle mass is associated with a loss of diverse functional abilities. Meanwhile, there have been limited studies concerning postural dysfunction among older adults with sarcopenia. Although sarcopenia is primarily a disease of the elderly, its development may be associated with conditions that are not exclusively seen in older persons. Also, recent studies recognize that sarcopenia may begin to develop earlier in life. The objective of this paper was to investigate the association between the prevalence of sarcopenia and postural dysfunction in a wide age range of adults using data from a nationally representative cohort study in Korea. Korean National Health & Nutrition Exhibition Survey V (KNHANES V, 2010-2012) data from the fifth cross-sectional survey of the South Korean population performed by the Korean Ministry of Health and Welfare were used. Appendicular skeletal muscle mass (ASM)/height (ht)2 was used to define sarcopenia, and the Modified Romberg test using a foam pad ("foam balance test") was performed to evaluate postural dysfunction. ASM/ht2 was lower in women and significantly decreased with age in men. Subjects with sarcopenia were significantly more likely to fail the foam balance test, regardless of sex and age. Regression analysis showed a significant relationship between sarcopenia and postural dysfunction (OR: 2.544, 95% CI: 1.683-3.846, p<0.001). Multivariate regression analysis revealed that sarcopenia (OR: 1.747, 95% CI: 1.120-2.720, p = 0.014) and age (OR: 1.131, 95% CI: 1.105-1.158, p<0.001) are independent risk factors for postural instability. In middle age subjects, the adjusted OR for sarcopenia was 3.344 (95% CI: 1.350-8.285) (p = 0.009). The prevalence of postural dysfunction is higher in sarcopenia patients, independent of sex and age.
姿势功能障碍是最常见的社区健康症状之一，也是医院中常见的主要主诉。肌少症是一种以骨骼肌质量、肌肉质量和肌肉力量进行性丧失为特征的综合征，是老年人肌肉骨骼功能障碍的主要原因。先前的研究表明，肌肉质量的丧失与多种功能能力的丧失有关。同时，关于肌少症老年人的姿势功能障碍的研究有限。尽管肌少症主要是一种老年病，但它的发展可能与老年人特有的疾病无关。此外，最近的研究认识到，肌少症可能早在生命早期就开始发展。本研究旨在使用来自韩国全国代表性队列研究的数据，调查广泛年龄范围的成年人中肌少症与姿势功能障碍之间的关联。本研究使用了韩国保健福利部进行的韩国人口第五次横断面调查（KNHANES V，2010-2012 年）的数据。四肢骨骼肌质量（ASM）/身高（ht）2 用于定义肌少症，使用泡沫垫进行改良 Romberg 测试（泡沫平衡测试）来评估姿势功能障碍。女性的 ASM/ht2 较低，且男性的 ASM/ht2 随年龄显著下降。无论性别和年龄，肌少症患者进行泡沫平衡测试的失败率显著更高。回归分析显示肌少症与姿势功能障碍之间存在显著关系（OR：2.544，95%CI：1.683-3.846，p<0.001）。多变量回归分析显示，肌少症（OR：1.747，95%CI：1.120-2.720，p = 0.014）和年龄（OR：1.131，95%CI：1.105-1.158，p<0.001）是姿势不稳定的独立危险因素。在中年人群中，肌少症的调整后 OR 为 3.344（95%CI：1.350-8.285）（p = 0.009）。姿势功能障碍在肌少症患者中的发生率更高，与性别和年龄无关。
