Dipartimento di Scienze e Tecnologie Agro-Alimentari (DISTAL), Università di Bologna, Viale G. Fanin 42, 40127 Bologna, Italy.
Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy.
Nutrients. 2020 May 7;12(5):1329. doi: 10.3390/nu12051329.
Irritable bowel syndrome (IBS) is a functional disorder without any pathological alteration, in which the alterations of the /s ratio of the gut microbiota, the balance of pro and anti-inflammatory cytokines and the brain-gut-microbiome axis are important for the development and progression of IBS. The aim of the study was to identify natural products, including essential oils or hydrolates, which were contextually harmless for the gut beneficial strains (e.g. spp.) but inhibitory for the pathogenic ones ( spp.).
The effectiveness of 6 essential oils and 2 hydrolates was evaluated using microbiological tests, carried out on 50 clinical isolates (, and species) and 9 probiotic strains (, , and ) and immunological and antioxidant assays.
The study led to a mixture based on a 1/100 ratio of var. essential oil / cv Italia hydrolate able to contextually reduce, in a concentration-dependent manner, the ability of species to form hyphal filaments and have an interesting immunomodulatory and anti-oxidant action. This mixture can potentially be useful in the IBS treatment promoting the restoration of the intestinal microbial and immunological balance.
肠易激综合征（IBS）是一种没有任何病理改变的功能性疾病，其中肠道微生物群的/s 比值、促炎和抗炎细胞因子的平衡以及脑-肠-微生物群轴的改变对于 IBS 的发展和进展很重要。本研究的目的是确定天然产物，包括精油或水醇提物，对肠道有益菌株（如 spp.）无害，但对致病菌株（ spp.）有抑制作用。
使用微生物学试验评估 6 种精油和 2 种水醇提物的有效性，该试验在 50 株临床分离株（、和 物种）和 9 株益生菌株（、、和 ）以及免疫和抗氧化试验上进行。
该研究产生了一种基于 1/100 比例的 var. 精油 / cv Italia 水醇提物的混合物，能够以浓度依赖的方式降低 物种形成菌丝体的能力，并具有有趣的免疫调节和抗氧化作用。这种混合物可能对 IBS 的治疗有用，促进肠道微生物和免疫平衡的恢复。
