Ibrahim Razaw O, Omer Shirwan H, Fattah Chro N
Department of Physiology, College of Medicine, University of Kirkuk, Kirkuk, Iraq.
Department of Physiology, College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq.
Int J Endocrinol. 2020 Jan 7;2020:6237141. doi: 10.1155/2020/6237141. eCollection 2020.
Kisspeptin is a neuropeptide that upregulates gonadotropin-releasing hormone (GnRH) secretion. It is an essential element for the luteinizing hormone (LH) surge and ovulation. Women with polycystic ovary syndrome (PCOS) expose alteration in both GnRH and LH secretion levels.
This paper aims to evaluate serum kisspeptin levels in healthy and polycystic ovarian syndrome women. Furthermore, it investigates the effect of obesity and age on circulating kisspeptin levels in both normal and PCOS women. Moreover, it points out the correlation between kisspeptin and other hormonal parameters. . One hundred women (60 are with PCOS and 40 are normal) were enrolled in the study. Five milliliter samples of blood from all the patients and control women were obtained twice during the menstrual cycle. All the study samples were classified depending on the age factor for several subgroups.
Kisspeptin levels were higher in PCOS patients than those in the normal group. Kisspeptin correlated with serum free testosterone level (=0.26). In healthy women, preovulatory kisspeptin levels were higher than follicular kisspeptin levels ( < 0.05), while this difference was insignificant in PCOS patients. The variation in serum kisspeptin levels between overweight/obese and normal-weight women was insignificant. In normal women, serum kisspeptin levels were higher in women >35 years than those <24 years at (=0.03).
The serum kisspeptin level is higher in PCOS women. Its levels fluctuate during the menstrual cycle, but these fluctuations are disturbed in PCOS women. The effect of BMI on serum kisspeptin levels is insignificant, and kisspeptin serum levels increase with age.
亲吻素是一种上调促性腺激素释放激素（GnRH）分泌的神经肽。它是促黄体生成素（LH）峰和排卵的关键要素。多囊卵巢综合征（PCOS）女性的GnRH和LH分泌水平均发生改变。
本文旨在评估健康女性和多囊卵巢综合征女性的血清亲吻素水平。此外，研究肥胖和年龄对正常女性和PCOS女性循环亲吻素水平的影响。而且，指出亲吻素与其他激素参数之间的相关性。100名女性（60名患有PCOS，40名正常）参与了该研究。在月经周期中，从所有患者和对照女性中采集两次5毫升血液样本。所有研究样本根据年龄因素分为几个亚组。
PCOS患者的亲吻素水平高于正常组。亲吻素与血清游离睾酮水平相关（=0.26）。在健康女性中，排卵前亲吻素水平高于卵泡期亲吻素水平（<0.05），而在PCOS患者中这种差异不显著。超重/肥胖女性与正常体重女性之间血清亲吻素水平的差异不显著。在正常女性中，年龄>35岁的女性血清亲吻素水平高于<24岁的女性（=0.03）。
PCOS女性的血清亲吻素水平较高。其水平在月经周期中波动，但在PCOS女性中这些波动受到干扰。BMI对血清亲吻素水平的影响不显著，且亲吻素血清水平随年龄增加。
