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具有全光学驱动和血液中跟踪功能的微型火箭机器人。

Micro-rocket robot with all-optic actuating and tracking in blood.

作者信息

Li Dengfeng, Liu Chao, Yang Yuanyuan, Wang Lidai, Shen Yajing

机构信息

1Department of Biomedical Engineering, City University of Hong Kong, 999077 Hong Kong, China.

2City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057 China.

出版信息

Light Sci Appl. 2020 May 11;9:84. doi: 10.1038/s41377-020-0323-y. eCollection 2020.

Abstract

Micro/nanorobots have long been expected to reach all parts of the human body through blood vessels for medical treatment or surgery. However, in the current stage, it is still challenging to drive a microrobot in viscous media at high speed and difficult to observe the shape and position of a single microrobot once it enters the bloodstream. Here, we propose a new micro-rocket robot and an all-optic driving and imaging system that can actuate and track it in blood with microscale resolution. To achieve a high driving force, we engineer the microrobot to have a rocket-like triple-tube structure. Owing to the interface design, the 3D-printed micro-rocket can reach a moving speed of 2.8 mm/s (62 body lengths per second) under near-infrared light actuation in a blood-mimicking viscous glycerol solution. We also show that the micro-rocket robot is successfully tracked at a 3.2-µm resolution with an optical-resolution photoacoustic microscope in blood. This work paves the way for microrobot design, actuation, and tracking in the blood environment, which may broaden the scope of microrobotic applications in the biomedical field.

摘要

长期以来,人们一直期望微型/纳米机器人能够通过血管到达人体的各个部位,以进行医疗治疗或手术。然而,在现阶段,在粘性介质中高速驱动微型机器人仍然具有挑战性,而且一旦单个微型机器人进入血液,就很难观察到它的形状和位置。在此,我们提出了一种新型微火箭机器人以及一种全光学驱动和成像系统,该系统能够在血液中以微米级分辨率驱动并跟踪它。为了实现高驱动力,我们将微型机器人设计成具有火箭状的三管结构。由于采用了界面设计,这种3D打印的微火箭在模拟血液的粘性甘油溶液中,在近红外光驱动下能够达到2.8毫米/秒的移动速度(每秒62个身体长度)。我们还展示了利用光学分辨率光声显微镜在血液中以3.2微米的分辨率成功跟踪微火箭机器人。这项工作为在血液环境中进行微型机器人的设计、驱动和跟踪铺平了道路,这可能会拓宽微型机器人在生物医学领域的应用范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd4/7214411/9e319e9bef6e/41377_2020_323_Fig1_HTML.jpg

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