一种由光声计算机断层扫描引导的微型机器人系统，用于肠道中的靶向导航。
A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines .
作者信息
Wu Zhiguang, Li Lei, Yang Yiran, Hu Peng, Li Yang, Yang So-Yoon, Wang Lihong V, Gao Wei
机构信息
Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
出版信息
Sci Robot. 2019 Jul 31;4(32). doi: 10.1126/scirobotics.aax0613. Epub 2019 Jul 24.
Recently, tremendous progress in synthetic micro/nanomotors in diverse environment has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control . Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines . The micromotors enveloped in microcapsules are stable in the stomach and exhibit efficient propulsion in various biofluids once released. The migration of micromotor capsules toward the targeted regions in intestines has been visualized by PACT in real time . Near-infrared light irradiation induces disintegration of the capsules to release the cargo-loaded micromotors. The intensive propulsion of the micromotors effectively prolongs the retention in intestines. The integration of the newly developed microrobotic system and PACT enables deep imaging and precise control of the micromotors and promises practical biomedical applications, such as drug delivery.
近年来，用于潜在生物医学应用的合成微纳马达在各种环境中取得了巨大进展。然而，现有的微纳马达平台在深部组织成像和运动控制方面效率低下。在此，我们展示了一种光声计算机断层扫描（PACT）引导的肠道微马达研究。包裹在微胶囊中的微马达在胃中稳定，一旦释放，在各种生物流体中表现出高效推进。微马达胶囊向肠道靶向区域的迁移已通过PACT实时可视化。近红外光照射会导致胶囊解体，从而释放装载有货物的微马达。微马达的强烈推进有效地延长了在肠道中的停留时间。新开发的微机器人系统与PACT的集成实现了对微马达的深度成像和精确控制，并有望应用于实际生物医学领域，如药物递送。
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