Centre National de la Recherche Scientifique, UMR CNRS 5287, F-33000 Bordeaux Cedex, France.
Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.
Int J Mol Sci. 2020 May 15;21(10):3500. doi: 10.3390/ijms21103500.
The International Journal of Molecular Sciences Special Issue "Serotonin in health and diseases" covers several aspects of the multiple and still mysterious functions of serotonin (5-hydroxytryptamine; 5-HT). 5-HT is neurotransmitter acting in the central nervous system (CNS), blood factor, and neurohormone controlling the function of several peripheral organs. Beyond its widespread implication in physiology, the 5-HT system is involved in numerous diseases of the CNS (e.g., depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson's disease) and peripheral organs (e.g., gastrointestinal disorders, cardiac arrhythmia, hypertension). The Special Issue includes 14 articles dealing with molecular and cellular effects of 5-HT in periphery and CNS, from functional aspects in lower animals to clinical practices. Beyond physiology, the Special Issue also covers the influence of 5-HT and its receptors in the mechanism of action of psychoactive molecules including antipsychotics, antidepressants, and drug of abuse. The recent progress made on the function and dysfunction of the 5-HT system will certainly increase the understanding of the widespread role of 5-HT ultimately leading to better apprehend its targeting in human diseases.
《国际分子科学杂志》特刊“血清素在健康和疾病中的作用”涵盖了血清素（5-羟色胺；5-HT）的多个方面，这些方面仍然具有神秘性。5-HT 是一种在中枢神经系统（CNS）中起作用的神经递质、血液因子和神经激素，它可以控制多个外周器官的功能。除了在生理学中的广泛应用外，5-HT 系统还涉及到中枢神经系统（如抑郁症、焦虑症、精神分裂症、强迫症、成瘾、帕金森病）和外周器官（如胃肠道疾病、心律失常、高血压）的许多疾病。本特刊共收录了 14 篇文章，涉及 5-HT 在中枢神经系统和外周组织中的分子和细胞作用，从较低等动物的功能方面到临床实践。除了生理学，本特刊还涵盖了 5-HT 及其受体在包括抗精神病药、抗抑郁药和滥用药物在内的精神活性分子作用机制中的影响。5-HT 系统功能和功能障碍的最新进展必将提高对 5-HT 广泛作用的认识，最终有助于更好地了解其在人类疾病中的靶向作用。
