Department of Family and Community Medicine, King Khalid University, Abha, Saudi Arabia.
Department of Medicine, King Khalid University, Abha, Saudi Arabia.
Oxid Med Cell Longev. 2020 Dec 23;2020:6640402. doi: 10.1155/2020/6640402. eCollection 2020.
Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. . A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique.
Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092-4.05) indicating a higher risk for the development of ASCVD among those patients.
Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.
甲状腺功能减退症被认为与血脂异常有关，被认为是动脉粥样硬化性心血管疾病（ASCVD）发展的危险因素。维生素 D 由于其甾体激素作用，保留细胞功能并控制脂质代谢。因此，本研究旨在显示 ASCVD 危险因素与甲状腺激素缺乏和维生素 D 水平之间的关联，因为之前尚未对沙特患者进行过此类研究。
对 400 例甲状腺功能减退症患者进行回顾性队列研究。对这些患者的病历进行随访，并根据其促甲状腺激素（TSH）水平将其分为正常和甲状腺功能减退症患者。使用 ELISA 技术测定 TSH、维生素 D 和血脂谱。
甲状腺功能减退症患者的总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平明显高于正常组。我们发现 TSH 水平与 ASCVD 的危险因素（总胆固醇、甘油三酯和 LDL-C）之间存在显著相关性。此外，还发现维生素 D 水平与 ASCVD 的危险因素（总胆固醇、甘油三酯和 LDL-C）之间存在显著相关性。此外，维生素 D 缺乏与低 TSH 水平之间存在相关性（95%CI 1.092-4.05），表明这些患者发生 ASCVD 的风险更高。
必须在早期定期筛查甲状腺功能减退症和维生素 D 缺乏症患者，以预测和预防心血管疾病。此外，应给予这些患者足够的维生素 D 和 TH，以在早期预防心血管疾病。
