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中波紫外线 NB-UVB 辐射可减轻银屑病的炎症反应。

NB-UVB irradiation attenuates inflammatory response in psoriasis.

机构信息

Dermatology Department, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China.

Department of Traditional Chinese Medicine Cosmetology, College of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China.

出版信息

Dermatol Ther. 2020 Jul;33(4):e13626. doi: 10.1111/dth.13626. Epub 2020 Jul 11.

DOI:10.1111/dth.13626
PMID:32431049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7507206/
Abstract

Psoriasis is a chronic inflammatory disease characterized by immunological imbalance and vasodilation. Many triggering factors for psoriasis initiate inflammation via the activation of NF-κB. Narrow-band ultraviolet B (NB-UVB) irradiation can be used as a general treatment for psoriasis, although the molecular mechanism has not yet been determined. The aim of this study was to elucidate the potential molecular mechanism of NB-UVB irradiation therapy on psoriasis. We collected serum samples from patients with psoriasis and healthy control, and detected the expression of inflammatory factors by ELISA. In addition, we established mouse model of psoriasis. After different doses of NB-UVB irradiation, the proportion of CD4 , CD8 , and CD11c cells in mouse spleen was detected by flow cytometry. Meanwhile, the expression of inflammatory factors in the damaged skin of mice was detected by RT-PCR and Western blot analysis, and mouse serum levels of inflammatory factors were detected by ELISA. Our results showed that NB-UVB irradiation regulated the expression of inflammatory factors in psoriasis patients. In mice, high-dose NB-UVB irradiation effectively eliminated IMQ-induced psoriasis-like dermatitis and inhibited the expression of pro-inflammatory factors. In conclusion, our results indicate that NB-UVB irradiation could regulate the expression of inflammatory factors and attenuate psoriasis plaques.

摘要

银屑病是一种慢性炎症性疾病，其特征为免疫失衡和血管扩张。许多银屑病的诱发因素通过激活 NF-κB 引发炎症。窄谱中波紫外线（NB-UVB）照射可作为银屑病的一般治疗方法，尽管其分子机制尚未确定。本研究旨在阐明 NB-UVB 照射治疗银屑病的潜在分子机制。我们收集了银屑病患者和健康对照者的血清样本，并通过 ELISA 检测了炎症因子的表达。此外，我们还建立了银屑病小鼠模型。在给予不同剂量的 NB-UVB 照射后，通过流式细胞术检测小鼠脾中 CD4+、CD8+和 CD11c 细胞的比例。同时，通过 RT-PCR 和 Western blot 分析检测小鼠皮肤损伤处炎症因子的表达，通过 ELISA 检测小鼠血清中炎症因子的水平。我们的结果表明，NB-UVB 照射调节了银屑病患者的炎症因子表达。在小鼠中，高剂量 NB-UVB 照射能有效消除 IMQ 诱导的银屑病样皮炎，并抑制促炎因子的表达。综上所述，我们的研究结果表明，NB-UVB 照射可调节炎症因子的表达，从而减轻银屑病斑块。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/08f30d1bf4b4/DTH-33-e13626-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/8c4276e71061/DTH-33-e13626-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/52550cea5d06/DTH-33-e13626-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/08f30d1bf4b4/DTH-33-e13626-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/8c4276e71061/DTH-33-e13626-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/52550cea5d06/DTH-33-e13626-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0430/7507206/08f30d1bf4b4/DTH-33-e13626-g003.jpg

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The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis.IL-17 在银屑病和银屑病关节炎发病机制中的免疫作用。
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