Mowforth Oliver D, Davies Benjamin M, Goh Samuel, O'Neill Cormac P, Kotter Mark R N
Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.
Joint first authors.
Global Spine J. 2020 Jun;10(4):476-485. doi: 10.1177/2192568219847439. Epub 2019 Jun 12.
Scoping review.
To describe activity, themes and trends in degenerative cervical myelopathy (DCM) research over the past 20 years with a view to considering DCM research inefficiency.
A systematic review of MEDLINE and Embase for "Cervical" AND "Myelopathy" was conducted following PRISMA guidelines. Full-text papers in English, exclusively studying DCM, published between January 1, 1995 and December 31, 2015 were considered eligible. Country of origin, number of papers published, number of patients studied, research theme, and year of publication were assessed. Comparison was made between developed and developing countries.
A total of 1485 papers and 4 117 051 patients were included. Japan published more papers (450) than any other country while the United States studied the greatest number of patients (3 674 737). Over 99.4% of papers and 78.6% of patients were from developed countries. The number of papers ( = 0.96, < .001) and patients ( = 0.83 < .001) studied each year increased significantly overall and for both developed ( = 0.93, < .001; = 0.81, < .001) and developing countries ( = 0.90, < .001; = 0.87, < .001). Surgery was the most prevalent theme (58.3% papers; 55.7% patients) for developed and developing countries. Research from developing countries showed greater thematic variability.
DCM research activity is increasing internationally, with surgery remaining the focus. Research output has predominantly been from developed countries; however, the rate of growth for developed and developing countries is comparable.
范围综述。
描述过去20年中退行性颈椎脊髓病(DCM)研究的活动、主题和趋势,以考量DCM研究的低效性。
按照PRISMA指南对MEDLINE和Embase数据库进行系统检索,检索词为“颈椎”和“脊髓病”。纳入1995年1月1日至2015年12月31日期间发表的、仅研究DCM的英文全文论文。评估论文的原产国、发表论文数量、研究患者数量、研究主题和发表年份。对发达国家和发展中国家进行比较。
共纳入1485篇论文和4117051例患者。日本发表的论文(450篇)比其他任何国家都多,而美国研究的患者数量最多(3674737例)。超过99.4%的论文和78.6%的患者来自发达国家。每年研究的论文数量(r = 0.96,P <.001)和患者数量(r = 0.83,P <.001)总体上显著增加,发达国家(r = 0.93,P <.001;r = 0.81,P <.001)和发展中国家(r = 0.90,P <.001;r = 0.87,P <.001)均如此。手术是发达国家和发展中国家最普遍的主题(58.3%的论文;55.7%的患者)。发展中国家的研究主题变异性更大。
DCM研究活动在国际上不断增加,手术仍是重点。研究成果主要来自发达国家;然而,发达国家和发展中国家的增长速度相当。