Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obes Res Clin Pract. 2020 May-Jun;14(3):249-256. doi: 10.1016/j.orcp.2020.04.002. Epub 2020 May 20.
Data shows that interactions between dietary factors and genetic variants can modulate the association of polymorphisms such as the Melanocortin-4 receptor (MC4R) gene with obesity. Considering the limited data available on this topic we aimed to investigate interactions between dietary patterns (DPs) and MC4R polymorphisms in relation to obesity phenotypes.
This cohort study was performed in the framework of Tehran Lipid and Glucose Study; for eligible participants in this study (n=3850), the median follow-up was 4 years. DPs were determined using factor analysis. The genotypes of polymorphisms (17782313rs and 12970134rs) were identified and their interaction with DPs were assessed in relation to incidence of obesity phenotypes including central obesity, general obesity and visceral adiposity dysfunction.
The mean age of participants (62.5% females) were 37.0±13.7 years. Two main DPs (healthy and unhealthy) were extracted. C-allele carriers of rs17782313 in higher quartiles of the healthy DP score had a significant decrease in the incidence of general obesity, compared to those who had the TT genotype (HR=0.61, 95% CI=0.42-0.89, P interaction=0.01). For rs12970134 A-allele carriers, subjects in the second compared to the first quartile of the healthy DP score, had a significant decrease in the incidence of general obesity (HR=0.68, 95% CI=0.46-0.99). There were no significant interaction between DPs and MC4R variants in relation to other obesity phenotypes.
Our results indicate that the healthy DP could interact with rs17782313 in relation to incidence of general obesity.
数据表明，饮食因素和遗传变异之间的相互作用可以调节多态性（如黑素皮质素 4 受体 [MC4R] 基因）与肥胖之间的关联。考虑到关于这一主题的有限数据，我们旨在研究饮食模式（DP）与 MC4R 多态性之间的相互作用与肥胖表型的关系。
本队列研究是在德黑兰血脂和血糖研究的框架内进行的；对于该研究的合格参与者（n=3850），中位随访时间为 4 年。使用因子分析确定 DP。鉴定多态性（17782313rs 和 12970134rs）的基因型，并评估其与肥胖表型（包括中心性肥胖、全身性肥胖和内脏脂肪功能障碍）发生的相互作用。
参与者的平均年龄（62.5%为女性）为 37.0±13.7 岁。提取了两个主要的 DP（健康和不健康）。在健康 DP 评分较高四分位数的 rs17782313 的 C 等位基因携带者中，与 TT 基因型相比，全身肥胖的发生率显著降低（HR=0.61，95%CI=0.42-0.89，P 交互=0.01）。对于 rs12970134 的 A 等位基因携带者，与健康 DP 评分的第一四分位相比，第二四分位的受试者的全身性肥胖发生率显著降低（HR=0.68，95%CI=0.46-0.99）。DP 和 MC4R 变异体之间没有与其他肥胖表型相关的显著相互作用。
我们的结果表明，健康 DP 可能与 rs17782313 相互作用，与全身肥胖的发生率有关。
