Gomes Fernanda, Dias Maria Inês, Lima Ângela, Barros Lillian, Rodrigues Maria Elisa, Ferreira Isabel C F R, Henriques Mariana
CEB, Centro de Engenharia Biológica, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, Universidade do Minho, 4710-057 Braga, Portugal.
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Antibiotics (Basel). 2020 May 31;9(6):294. doi: 10.3390/antibiotics9060294.
Medicinal and aromatic plants are known to have a wide range of uses and health benefits, and should be exploited for their bioactivity. Here we evaluated the antimicrobial activity of decoctions of L. and L. against Gram-positive and Gram-negative bacteria and spp. as well as their mechanism of action and phenolic characterization. The and extracts were effective against a broad set of species, including the Gram-positive , and and the Gram-negative and . Both extracts were found to have rosmarinic acid as the main phenolic compound and to exert their antimicrobial activity at the level of the cell membrane. Membrane perturbations by the extracts impaired cell membrane integrity only a few hours after exposure. This study confirms the bioactive potential of and decoctions, and supports the development of novel formulations with wide antimicrobial properties based on these medicinal and aromatic herbs.
药用植物和芳香植物具有广泛的用途和健康益处，应利用其生物活性。在此，我们评估了[两种植物拉丁文名]煎剂对革兰氏阳性菌和革兰氏阴性菌以及[某种菌拉丁文名]的抗菌活性、作用机制和酚类特征。[两种植物拉丁文名]提取物对多种菌株有效，包括革兰氏阳性菌[几种菌拉丁文名]和革兰氏阴性菌[几种菌拉丁文名]。两种提取物均以迷迭香酸作为主要酚类化合物，并在细胞膜水平发挥抗菌活性。提取物引起的膜扰动在暴露后仅数小时就损害了细胞膜完整性。本研究证实了[两种植物拉丁文名]煎剂的生物活性潜力，并支持基于这些药用和芳香草药开发具有广泛抗菌特性的新型制剂。
