Department of Pathology, University of Louisville, Louisville, KY, U.S.A.
Anticancer Res. 2020 Jun;40(6):3139-3145. doi: 10.21873/anticanres.14295.
BACKGROUND/AIM: The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans.
We used five different glucans isolated from algae, yeast, bacteria, oat, and mushroom. We compared their effects on the stimulation of phagocytosis of blood cells, on the secretion of IL-2, and on the inhibition of melanoma and breast and lung cancers. In addition, we evaluated the effects of glucan supplementation on two experimental models of infection.
Most of the tested glucans stimulated phagocytosis and IL-2 secretion, reduced cancer growth, and ameliorated some effects of experimental infections.
Glucans can produce significant pleiotropic effects, but the activity varies among individual samples.
背景/目的：本研究旨在直接比较五种市售葡聚糖的抗感染和抗癌作用。
我们使用了五种不同的从藻类、酵母、细菌、燕麦和蘑菇中分离得到的葡聚糖。我们比较了它们对血细胞吞噬作用的刺激、IL-2 分泌的影响，以及对黑色素瘤和乳腺癌、肺癌的抑制作用。此外，我们还评估了葡聚糖补充对两种感染实验模型的影响。
大多数测试的葡聚糖刺激了吞噬作用和 IL-2 的分泌，减少了癌症的生长，并改善了一些实验感染的影响。
葡聚糖可以产生显著的多效性作用，但个体样本之间的活性存在差异。
