Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
J Perinatol. 2021 Feb;41(2):232-239. doi: 10.1038/s41372-020-0704-3. Epub 2020 Jun 3.
To evaluate the effects of gestational age (GA) and postnatal age on skin barrier integrity by comparing premature infants at full-term corrected age with infants born at term.
Parallel comparison of chest skin in 36 premature infants with 39 full-term infants using daily measures of transepidermal water loss (TEWL), skin pH, erythema and rash, over 2 weeks.
Chest skin pH was significantly lower for premature infants, indicating that acid mantle formation had occurred in the premature versus full-term infants. Chest TEWL was significantly higher for premature versus full-term infants over 2 weeks, suggesting that even 7-8 weeks after birth, skin integrity is poorer in premature infants.
Skin barrier properties of premature infants at adjusted full-term age differ from full-term infants, suggesting that epidermal barrier development depends on GA and time from birth. These maturational differences may influence premature infant response to topical agents.
通过比较足月校正年龄的早产儿和足月出生的婴儿，评估胎龄（GA）和生后年龄对皮肤屏障完整性的影响。
对 36 名早产儿和 39 名足月婴儿的胸部皮肤进行平行比较，在 2 周内每天测量经皮水分丢失（TEWL）、皮肤 pH 值、红斑和皮疹。
早产儿的胸部皮肤 pH 值明显较低，表明早产儿与足月婴儿相比，酸衣的形成已经发生。早产儿在 2 周内的 TEWL 明显高于足月婴儿，这表明即使在出生后 7-8 周，早产儿的皮肤完整性仍然较差。
校正足月年龄的早产儿的皮肤屏障特性与足月婴儿不同，这表明表皮屏障的发育取决于 GA 和出生后的时间。这些成熟差异可能会影响早产儿对外用药物的反应。
