中年时的胆固醇和甘油三酯水平与女性心力衰竭风险的关系：前瞻性哥德堡女性人群研究。
Cholesterol and triglyceride levels in midlife and risk of heart failure in women, a longitudinal study: the prospective population study of women in Gothenburg.
机构信息
Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden.
出版信息
BMJ Open. 2020 Jun 4;10(6):e036709. doi: 10.1136/bmjopen-2019-036709.
OBJECTIVE
To examine the association between triglycerides and cholesterol serum values and risk of developing heart failure in women.
DESIGN
Longitudinal observational study of four cohorts 50-year-old women examined in 1968-1969, 1980-1981, 1992-1993 and 2004-2005, and followed until 2012. S-triglycerides and s-cholesterol were measured at baseline and heart failure morbidity and mortality data collected from 1980 to 2012.
SETTING
Prospective population study Gothenburg, Sweden. Primary care.
PARTICIPANTS
1143 women 50 year old without history of heart failure or myocardial infarction.
MAIN OUTCOME MEASURE
Association among s-triglycerides, s-cholesterol and heart failure expressed as HR for heart failure, adjusted for smoking, body mass index (BMI), physical activity and age.
RESULTS
For 50-year-old women examined in 1968-1969, there was an independent association between level of s-triglycerides and heart failure and a significantly higher risk of developing heart failure (HR 1.8; CI 1.16 to 2.80, for each increment of 1.0 mmol/L in s-triglycerides), adjusted for smoking, BMI, physical activity and age. There was no significant association between s-cholesterol and risk of heart failure (HR 0.9; CI 0.77 to 1.15). In the cohorts of 50-year-old women examined in 1980 and 1992, there were no significant associations between neither s-triglycerides or s-cholesterol and the risk of heart failure. In the pooled analyses of the cohorts examined in 1968, 1980 and 1992, a significantly increased risk of heart failure was found (HR 1.49; CI 1.10 to 2.03) for s-triglycerides independently, but not for s-cholesterol. None of the 50-year-old women examined in 2004-2005 developed heart failure by 2012 and were excluded from further analyses.
CONCLUSIONS
High levels of s-triglycerides but not s-cholesterol may be a risk marker for later development of heart failure in 50-year-old women.
目的
探讨血清甘油三酯和胆固醇值与女性心力衰竭风险的关系。
设计
对 1968-1969 年、1980-1981 年、1992-1993 年和 2004-2005 年接受检查的 50 岁女性进行的四项队列的纵向观察性研究，并随访至 2012 年。在基线时测量 S-甘油三酯和 S-胆固醇，并从 1980 年至 2012 年收集心力衰竭发病率和死亡率数据。
地点
瑞典哥德堡的前瞻性人群研究。初级保健。
参与者
1143 名无心力衰竭或心肌梗死病史的 50 岁女性。
主要观察指标
S-甘油三酯、S-胆固醇与心力衰竭之间的关系，用心力衰竭的 HR 表示，调整了吸烟、体重指数（BMI）、体力活动和年龄。
结果
对于 1968-1969 年接受检查的 50 岁女性，S-甘油三酯水平与心力衰竭之间存在独立的关联，且发展心力衰竭的风险显著增加（每增加 1.0mmol/L S-甘油三酯，HR 为 1.8；95%CI 为 1.16 至 2.80），调整了吸烟、BMI、体力活动和年龄。S-胆固醇与心力衰竭风险之间无显著关联（HR 0.9；95%CI 为 0.77 至 1.15）。在 1980 年和 1992 年接受检查的 50 岁女性队列中，S-甘油三酯或 S-胆固醇与心力衰竭风险之间均无显著关联。在对 1968 年、1980 年和 1992 年接受检查的队列的汇总分析中，S-甘油三酯独立地发现心力衰竭风险显著增加（HR 1.49；95%CI 为 1.10 至 2.03），而 S-胆固醇则没有。2004-2005 年接受检查的 50 岁女性均未在 2012 年发生心力衰竭，因此未纳入进一步分析。
结论
高水平的 S-甘油三酯但不是 S-胆固醇可能是 50 岁女性心力衰竭后发展的风险标志物。
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