唾液作为一种诊断液。
Saliva as a diagnostic fluid.
作者信息
Malamud Daniel
机构信息
Department of Basic Sciences, New York University College of Dentistry, New York, NY 10010, USA.
出版信息
Dent Clin North Am. 2011 Jan;55(1):159-78. doi: 10.1016/j.cden.2010.08.004.
Abstract
Salivary diagnostics is a dynamic and emerging field utilizing nanotechnology and molecular diagnostics to aid in the diagnosis of oral and systemic diseases. In this article the author critically reviews the latest advances using oral biomarkers for disease detection. The use of oral fluids is broadening perspectives in clinical diagnosis, disease monitoring, and decision making for patient care. Important elements determining the future possibilities and challenges in this field are also discussed.
摘要
唾液诊断是一个利用纳米技术和分子诊断来辅助口腔及全身性疾病诊断的动态且新兴的领域。在本文中，作者批判性地回顾了使用口腔生物标志物进行疾病检测的最新进展。口腔液体的使用正在拓宽临床诊断、疾病监测以及患者护理决策方面的视野。本文还讨论了决定该领域未来可能性和挑战的重要因素。
相似文献
1
Saliva as a diagnostic fluid.唾液作为一种诊断液。
Dent Clin North Am. 2011 Jan;55(1):159-78. doi: 10.1016/j.cden.2010.08.004.
2
Salivary biomarkers--an update.唾液生物标志物——最新进展
Dent Update. 2012 Oct;39(8):566-8, 571-2. doi: 10.12968/denu.2012.39.8.566.
3
[The role of biochemical study of the saliva in diagnosing diseases].[唾液生化研究在疾病诊断中的作用]
Klin Lab Diagn. 1998 Jun(6):18-20.
4
Salivary diagnostics powered by nanotechnologies, proteomics and genomics.由纳米技术、蛋白质组学和基因组学驱动的唾液诊断技术。
J Am Dent Assoc. 2006 Mar;137(3):313-21. doi: 10.14219/jada.archive.2006.0180.
5
Salivary biomarkers: toward future clinical and diagnostic utilities.唾液生物标志物：未来的临床和诊断应用。
Clin Microbiol Rev. 2013 Oct;26(4):781-91. doi: 10.1128/CMR.00021-13.
6
Saliva: an emerging biofluid for early detection of diseases.唾液：一种用于疾病早期检测的新兴生物流体。
Am J Dent. 2009 Aug;22(4):241-8.
7
The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications.口腔液体微机电系统/纳机电系统芯片（OFMNC）：诊断及转化应用
Adv Dent Res. 2005 Jun;18(1):3-5. doi: 10.1177/154407370501800102.
8
Salivary diagnostics.唾液诊断学。
Orthod Craniofac Res. 2009 Aug;12(3):206-11. doi: 10.1111/j.1601-6343.2009.01454.x.
9
Utility of salivary biomarkers for demonstrating acute myocardial infarction.唾液生物标志物在诊断急性心肌梗死中的应用
J Dent Res. 2014 Jul;93(7 Suppl):72S-79S. doi: 10.1177/0022034514537522. Epub 2014 May 30.
10
Current development of saliva/oral fluid-based diagnostics.基于唾液/口腔液诊断方法的当前发展状况。
Tex Dent J. 2010 Jul;127(7):651-61.
引用本文的文献
1
Salivary α-Amylase as a Metabolic Biomarker: Analytical Tools, Challenges, and Clinical Perspectives.唾液α淀粉酶作为一种代谢生物标志物：分析工具、挑战及临床前景
Int J Mol Sci. 2025 Jul 30;26(15):7365. doi: 10.3390/ijms26157365.
2
Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.精神障碍中口腔微生物群组成的改变：一项系统评价和荟萃分析。
J Oral Microbiol. 2025 Aug 3;17(1):2541828. doi: 10.1080/20002297.2025.2541828. eCollection 2025.
3
Salivary Interleukins as Non-Invasive Biomarkers for Psoriasis: Advances and Challenges in Diagnosis and Monitoring.唾液白细胞介素作为银屑病的非侵入性生物标志物：诊断与监测的进展及挑战
Medicina (Kaunas). 2025 Jun 29;61(7):1180. doi: 10.3390/medicina61071180.
4
Exploring Salivary Thiocyanate as a Novel Biomarker of Physical Activity Response.探索唾液硫氰酸盐作为身体活动反应的新型生物标志物。
Molecules. 2025 Jun 5;30(11):2476. doi: 10.3390/molecules30112476.
5
The Role of Salivary Diagnostic Techniques in Screening for Active Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis.唾液诊断技术在活动性肺结核筛查中的作用：一项系统评价与荟萃分析
Microorganisms. 2025 Apr 24;13(5):973. doi: 10.3390/microorganisms13050973.
6
Prevalence of Torque Teno Virus in Portuguese Children Younger Than 3 Years Old: A Single-Center Study.葡萄牙3岁以下儿童中细小病毒的流行情况：一项单中心研究。
Clin Pediatr (Phila). 2025 Oct;64(10):1419-1424. doi: 10.1177/00099228251339047. Epub 2025 May 9.
7
Chemical Sensors and Biosensors for Point-of-Care Testing of Pets: Opportunities for Individualized Diagnostics of Companion Animals.用于宠物即时检测的化学传感器和生物传感器：伴侣动物个性化诊断的机遇
ACS Sens. 2025 May 23;10(5):3222-3238. doi: 10.1021/acssensors.4c03664. Epub 2025 Apr 22.
8
Salivary diagnostics: Bridging dentistry and medicine: A systematic review.唾液诊断：连接牙科与医学：一项系统评价。
Bioinformation. 2024 Dec 31;20(12):1754-1759. doi: 10.6026/9732063002001754. eCollection 2024.
9
Laboratory evaluation of oral fluid for syphilis screening among clinic users from Lima, Peru.秘鲁利马诊所使用者中用于梅毒筛查的口腔液实验室评估。
Microbiol Spectr. 2025 Jan 7;13(1):e0129824. doi: 10.1128/spectrum.01298-24. Epub 2024 Dec 10.
10
Salivary diagnostics: opportunities and challenges.唾液诊断：机遇与挑战。
Theranostics. 2024 Oct 21;14(18):6969-6990. doi: 10.7150/thno.100600. eCollection 2024.
本文引用的文献
1
Application of mtDNA SNP analysis in forensic casework.mtDNA SNP 分析在法医学中的应用。
Forensic Sci Int Genet. 2011 Jun;5(3):216-21. doi: 10.1016/j.fsigen.2010.01.015. Epub 2010 Feb 18.
2
Salivary progesterone levels before menarche: a prospective study of adolescent girls.月经初潮前的唾液孕酮水平：对青春期少女的前瞻性研究。
J Clin Endocrinol Metab. 2010 Jul;95(7):3507-11. doi: 10.1210/jc.2010-0125. Epub 2010 Apr 28.
3
[Diagnosis and treatment of oral candidosis].[口腔念珠菌病的诊断与治疗]
Duodecim. 2010;126(2):174-80.
4
An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids.一种集成的、自包含的微流控盒，用于核酸的分离、扩增和检测。
Biomed Microdevices. 2010 Aug;12(4):705-19. doi: 10.1007/s10544-010-9423-4.
5
Biofilm formation and virulence expression by Streptococcus mutans are altered when grown in dual-species model.当变形链球菌在双物种模型中生长时，其生物膜形成和毒力表达会发生改变。
BMC Microbiol. 2010 Apr 14;10:111. doi: 10.1186/1471-2180-10-111.
6
Biomarkers in tongue cancer: understanding the molecular basis and their clinical implications.舌癌的生物标志物：解析分子基础及其临床意义。
Postgrad Med J. 2010 May;86(1015):292-8. doi: 10.1136/pgmj.2009.086504. Epub 2010 Apr 14.
7
Current developments in salivary diagnostics.唾液诊断学的最新进展。
Biomark Med. 2010 Feb;4(1):171-89. doi: 10.2217/bmm.09.68.
8
Infectious and dietary risk factors of oral cancer.口腔癌的感染和饮食危险因素。
Oral Oncol. 2010 Jun;46(6):411-3. doi: 10.1016/j.oraloncology.2010.03.003. Epub 2010 Apr 8.
9
Diagnostic clinical aids in oral cancer.口腔癌的诊断临床辅助工具。
Oral Oncol. 2010 Jun;46(6):418-22. doi: 10.1016/j.oraloncology.2010.03.006. Epub 2010 Apr 3.
10
Toluidine blue color perception in identification of oral mucosal lesions.甲苯胺蓝显色在口腔黏膜病损识别中的应用。
Clin Oral Investig. 2011 Jun;15(3):337-45. doi: 10.1007/s00784-010-0398-6. Epub 2010 Mar 25.
Zotero 插件