Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sci Rep. 2020 Jun 9;10(1):9311. doi: 10.1038/s41598-020-66284-3.
Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR < 0.009). Associations for triglyceride, HDL-cholesterol, glucose and blood pressure were not. Linearity was confirmed for significant associations. Exposure to EDCs in the Dutch population is ubiquitous. We found direct associations between phthalates and adiposity-related traits. Prospective studies are needed to confirm these findings.
内分泌干扰化学物质（EDCs）与多种心血管代谢疾病有关。然而，很少有研究考虑生活方式来调查 EDC 暴露与心血管代谢健康之间的关系。我们旨在评估荷兰一般人群中五种对羟基苯甲酸酯、三种双酚和总共 13 种邻苯二甲酸酯代谢物的暴露情况，并研究它们与心血管代谢特征的关系。在来自基于人群的 Lifelines 队列的 662 名成年受试者中，在 2012 年收集的 24 小时尿液中使用 LC-MS/MS 测量了 21 种 EDC 分析物。使用多元线性模型调整年龄、性别、教育、吸烟、糖尿病、体力活动和热量摄入后，进行了心血管代谢特征与 EDC 浓度之间的关联分析。进行四分位分析以评估线性关系。双酚 A、四种对羟基苯甲酸酯和八种邻苯二甲酸酯代谢物在 84-100%的样本中被检测到。MiBP 和 MBzP 与肥胖相关特征的调整关联在多重检验中是稳健的（Beta，BMI：1.12，2.52；腰围：0.64，1.56，分别；FDR<0.009）。甘油三酯、高密度脂蛋白胆固醇、葡萄糖和血压的关联则不然。对于显著关联，线性关系得到了确认。荷兰人群中 EDC 的暴露是普遍存在的。我们发现了邻苯二甲酸酯与肥胖相关特征之间的直接关联。需要进行前瞻性研究来证实这些发现。
