骨骼干细胞在骨再生中的当前及未来应用
Current and future uses of skeletal stem cells for bone regeneration.
作者信息
Xu Guo-Ping, Zhang Xiang-Feng, Sun Lu, Chen Er-Man
机构信息
Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China.
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, United States.
出版信息
World J Stem Cells. 2020 May 26;12(5):339-350. doi: 10.4252/wjsc.v12.i5.339.
Abstract
The postnatal skeleton undergoes growth, modeling, and remodeling. The human skeleton is a composite of diverse tissue types, including bone, cartilage, fat, fibroblasts, nerves, blood vessels, and hematopoietic cells. Fracture nonunion and bone defects are among the most challenging clinical problems in orthopedic trauma. The incidence of nonunion or bone defects following fractures is increasing. Stem and progenitor cells mediate homeostasis and regeneration in postnatal tissue, including bone tissue. As multipotent stem cells, skeletal stem cells (SSCs) have a strong effect on the growth, differentiation, and repair of bone regeneration. In recent years, a number of important studies have characterized the hierarchy, differential potential, and bone formation of SSCs. Here, we describe studies on and applications of SSCs and/or mesenchymal stem cells for bone regeneration.
摘要
出生后的骨骼会经历生长、塑形和重塑过程。人体骨骼是多种组织类型的复合体，包括骨、软骨、脂肪、成纤维细胞、神经、血管和造血细胞。骨折不愈合和骨缺损是骨科创伤中最具挑战性的临床问题。骨折后不愈合或骨缺损的发生率正在上升。干细胞和祖细胞介导出生后组织（包括骨组织）的内稳态和再生。作为多能干细胞，骨骼干细胞（SSCs）对骨再生的生长、分化和修复具有强大作用。近年来，一些重要研究已经对SSCs的层级结构、分化潜能和骨形成进行了表征。在此，我们描述了关于SSCs和/或间充质干细胞用于骨再生的研究及应用。
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