小鼠运动神经元和运动单位亚型的分子与电生理特性
Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes.
作者信息
Manuel Marin, Zytnicki Daniel
机构信息
Center for Neurophysics, Physiology and Pathology, Paris Descartes University, CNRS UMR 8119, Paris, France.
出版信息
Curr Opin Physiol. 2019 Apr;8:23-29. doi: 10.1016/j.cophys.2018.11.008. Epub 2018 Dec 1.
Abstract
The field of motoneuron and motor unit physiology in mammals has deeply evolved the last decade thanks to the parallel development of mouse genetics and transcriptomic analysis and of mouse preparations that allow intracellular electrophysiological recordings of motoneurons. We review the efforts made to investigate the electrophysiological properties of the different functional subtypes of mouse motoneurons, to decipher the mosaic of molecular markers specifically expressed in each subtype, and to elucidate which of those factors drive the identity of motoneurons.
摘要
在过去十年中，得益于小鼠遗传学和转录组分析以及能够对运动神经元进行细胞内电生理记录的小鼠制备技术的并行发展，哺乳动物运动神经元和运动单位生理学领域有了深入的发展。我们回顾了在研究小鼠运动神经元不同功能亚型的电生理特性、解读每个亚型中特异性表达的分子标志物的镶嵌图谱以及阐明哪些因素决定运动神经元身份等方面所做的努力。
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