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Are Genetic Vaccines the Right Weapon against COVID-19?

作者信息

Conforti Antonella, Marra Emanuele, Roscilli Giuseppe, Palombo Fabio, Ciliberto Gennaro, Aurisicchio Luigi

机构信息

Evvivax, Rome, Italy; Vitares, Rome, Italy.

Takis, Rome, Italy; Vitares, Rome, Italy.

出版信息

Mol Ther. 2020 Jul 8;28(7):1555-1556. doi: 10.1016/j.ymthe.2020.06.007. Epub 2020 Jun 10.

DOI:10.1016/j.ymthe.2020.06.007
PMID:32553431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7283060/
Abstract
摘要

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Developing Covid-19 Vaccines at Pandemic Speed.以大流行速度研发新冠疫苗。
N Engl J Med. 2020 May 21;382(21):1969-1973. doi: 10.1056/NEJMp2005630. Epub 2020 Mar 30.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.新型冠状病毒感染肺炎在中国武汉的早期传播动力学。
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A Comparison of Plasmid DNA and mRNA as Vaccine Technologies.质粒DNA与mRNA作为疫苗技术的比较
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Nat Commun. 2018 Jun 22;9(1):2441. doi: 10.1038/s41467-018-04859-5.
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The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic.首个获批上市的癌症基因治疗药物——重组人 p53 腺病毒注射液（今又生）：12 年临床应用之路
Hum Gene Ther. 2018 Feb;29(2):160-179. doi: 10.1089/hum.2017.218.
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Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.线性犬骨 DNA 疫苗在临床前模型中诱导与传统质粒 DNA 相似的免疫反应，而不受 TLR9 的免疫识别影响。
Cancer Immunol Immunother. 2018 Apr;67(4):627-638. doi: 10.1007/s00262-017-2111-y. Epub 2018 Jan 12.
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Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.在利比里亚进行的两种预防埃博拉疫苗的2期安慰剂对照试验。
N Engl J Med. 2017 Oct 12;377(15):1438-1447. doi: 10.1056/NEJMoa1614067.
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Interval Between Infections and Viral Hierarchy Are Determinants of Viral Interference Following Influenza Virus Infection in a Ferret Model.感染间隔和病毒层级是雪貂模型中流感病毒感染后病毒干扰的决定因素。
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Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome.开发用于严重急性呼吸系统综合征的重组冠状病毒 S 蛋白受体结合域疫苗的路线图。
Expert Rev Vaccines. 2012 Dec;11(12):1405-13. doi: 10.1586/erv.12.126.